Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia.
<h4>Objective</h4>Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0268720 |
| _version_ | 1797867546661093376 |
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| author | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C Walker Sanjay M Sisodiya Simona Balestrini Umesh Vivekananda |
| author_facet | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C Walker Sanjay M Sisodiya Simona Balestrini Umesh Vivekananda |
| author_sort | Josephine Poole |
| collection | DOAJ |
| description | <h4>Objective</h4>Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect.<h4>Methods</h4>We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep.<h4>Results</h4>We found 1) hemispheric differences in pre-ictal and ictal spectral power (p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p = 0.017) and 26% increased delta power (p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p = 0.0003).<h4>Conclusions</h4>There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted.<h4>Significance</h4>Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC. |
| first_indexed | 2024-04-09T23:42:58Z |
| format | Article |
| id | doaj.art-b14af44cfada4dde891ba9f02f83b6bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T23:42:58Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b14af44cfada4dde891ba9f02f83b6bd2023-03-18T05:32:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e026872010.1371/journal.pone.0268720Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia.Josephine PooleSara ZagagliaRita DemurtasFiona FarrellMatthew C WalkerSanjay M SisodiyaSimona BalestriniUmesh Vivekananda<h4>Objective</h4>Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect.<h4>Methods</h4>We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep.<h4>Results</h4>We found 1) hemispheric differences in pre-ictal and ictal spectral power (p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p = 0.017) and 26% increased delta power (p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p = 0.0003).<h4>Conclusions</h4>There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted.<h4>Significance</h4>Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC.https://doi.org/10.1371/journal.pone.0268720 |
| spellingShingle | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C Walker Sanjay M Sisodiya Simona Balestrini Umesh Vivekananda Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. PLoS ONE |
| title | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. |
| title_full | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. |
| title_fullStr | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. |
| title_full_unstemmed | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. |
| title_short | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. |
| title_sort | alternating hemiplegia of childhood an electroclinical study of sleep and hemiplegia |
| url | https://doi.org/10.1371/journal.pone.0268720 |
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