The Transition of Photoreceptor Guanylate Cyclase Type 1 to the Active State

The Transition of Photoreceptor Guanylate Cyclase Type 1 to the Active State

Membrane-bound guanylate cyclases (GCs), which synthesize the second messenger guanosine-3′, 5′-cyclic monophosphate, differ in their activation modes to reach the active state. Hormone peptides bind to the extracellular domain in hormone-receptor-type GCs and trigger a conformational change in the...

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Bibliographic Details
Main Authors: Manisha Kumari Shahu, Fabian Schuhmann, Alexander Scholten, Ilia A. Solov’yov, Karl-Wilhelm Koch
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
guanylate cyclase
cGMP
calcium-binding proteins
phototransduction
retinal degeneration
vision
Online Access:https://www.mdpi.com/1422-0067/23/7/4030

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