P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS
Objective: The aim of this study was to evaluate predictive value of main arterial markers for cardiovascular (CV) events in subjects with metabolic syndrome (MetS). Methods: A prospective study enrolled 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS patients of the Lithuanian High Cardiov...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930073/view |
| _version_ | 1828398904815648768 |
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| author | Ligita Ryliškytė Rokas Navickas Roma Puronaitė Agnė Jucevičienė Aleksandras Laucevičius |
| author_facet | Ligita Ryliškytė Rokas Navickas Roma Puronaitė Agnė Jucevičienė Aleksandras Laucevičius |
| author_sort | Ligita Ryliškytė |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate predictive value of main arterial markers for cardiovascular (CV) events in subjects with metabolic syndrome (MetS).
Methods: A prospective study enrolled 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS patients of the Lithuanian High Cardiovascular Risk primary prevention program without overt CV disease. Subjects were followed-up for 3.9 ± 1.7 years for fatal or non-fatal myocardial infarction (MI) or stroke after their initial assessment including evaluation of carotid intima-media thickness (cIMT), aortic augmentation index (AIx), aortic pulse wave velocity (aPWV), brachial flow-mediated dilatation (FMD), carotid stiffness index, and cardio-ankle vascular index (CAVI).
Results: 83 (3%) patients had at least one cardiovascular event during the follow-up period. Univariate analysis showed association of CV events with higher mean blood pressure, aPWV, AIx, cIMT, and lower FMD (all p < 0.05). Cox proportional hazard regression analysis revealed association between CV events, increase in cIMT (HR 1.31, 95% CI 1.14–1.50, p < 0.001), aPWV (HR 1.29, 95% CI 1.04–1.60, p = 0.019), AIx (HR 1.53, 95% CI 1.16–2.02, p = 0.003) and decrease in FMD (HR 0.83, 95% CI 0.71–0.97, p = 0.016) even after the adjustment for age, gender, and common CV risk factors.
Using two-level survival trees analysis, we discovered relation between cIMT > 794 and higher CV risk (p < 0.001) and even higher risk with aPWV > 11.1 m/s (p = 0.023). Whereas cIMT£794 mcm together with the FMD cut-off point of 6.5% also resulted in higher risk (p = 0.003).
Conclusions: Our follow-up study reveals association between CV risk, increased aortic PWV, cIMT and decreased brachial FMD among middle-aged MetS patients. |
| first_indexed | 2024-12-10T09:09:57Z |
| format | Article |
| id | doaj.art-b14bdb2b4cee4dc2b832cc85e66c0598 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-10T09:09:57Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-b14bdb2b4cee4dc2b832cc85e66c05982022-12-22T01:55:03ZengBMCArtery Research1876-44012018-12-012410.1016/j.artres.2018.10.122P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTSLigita RyliškytėRokas NavickasRoma PuronaitėAgnė JucevičienėAleksandras LaucevičiusObjective: The aim of this study was to evaluate predictive value of main arterial markers for cardiovascular (CV) events in subjects with metabolic syndrome (MetS). Methods: A prospective study enrolled 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS patients of the Lithuanian High Cardiovascular Risk primary prevention program without overt CV disease. Subjects were followed-up for 3.9 ± 1.7 years for fatal or non-fatal myocardial infarction (MI) or stroke after their initial assessment including evaluation of carotid intima-media thickness (cIMT), aortic augmentation index (AIx), aortic pulse wave velocity (aPWV), brachial flow-mediated dilatation (FMD), carotid stiffness index, and cardio-ankle vascular index (CAVI). Results: 83 (3%) patients had at least one cardiovascular event during the follow-up period. Univariate analysis showed association of CV events with higher mean blood pressure, aPWV, AIx, cIMT, and lower FMD (all p < 0.05). Cox proportional hazard regression analysis revealed association between CV events, increase in cIMT (HR 1.31, 95% CI 1.14–1.50, p < 0.001), aPWV (HR 1.29, 95% CI 1.04–1.60, p = 0.019), AIx (HR 1.53, 95% CI 1.16–2.02, p = 0.003) and decrease in FMD (HR 0.83, 95% CI 0.71–0.97, p = 0.016) even after the adjustment for age, gender, and common CV risk factors. Using two-level survival trees analysis, we discovered relation between cIMT > 794 and higher CV risk (p < 0.001) and even higher risk with aPWV > 11.1 m/s (p = 0.023). Whereas cIMT£794 mcm together with the FMD cut-off point of 6.5% also resulted in higher risk (p = 0.003). Conclusions: Our follow-up study reveals association between CV risk, increased aortic PWV, cIMT and decreased brachial FMD among middle-aged MetS patients.https://www.atlantis-press.com/article/125930073/view |
| spellingShingle | Ligita Ryliškytė Rokas Navickas Roma Puronaitė Agnė Jucevičienė Aleksandras Laucevičius P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS Artery Research |
| title | P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS |
| title_full | P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS |
| title_fullStr | P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS |
| title_full_unstemmed | P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS |
| title_short | P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS |
| title_sort | p69 relationship between carotid intima media thickness endothelial function aortic stiffness and cardiovascular events among metabolic syndrome subjects |
| url | https://www.atlantis-press.com/article/125930073/view |
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