Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults
Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant. Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Cro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322006753 |
| _version_ | 1811214812039872512 |
|---|---|
| author | Fu-Rong Li Ke-Yi Wu Wei-Dong Fan Guo-Chong Chen Haili Tian Xian-Bo Wu |
| author_facet | Fu-Rong Li Ke-Yi Wu Wei-Dong Fan Guo-Chong Chen Haili Tian Xian-Bo Wu |
| author_sort | Fu-Rong Li |
| collection | DOAJ |
| description | Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant. Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Crohn’s disease, two subtypes of IBD, among middle and old aged adults in the UK. We also explored potential susceptible subgroups. Methods: We used data from the UK Biobank study. Information on air pollution, including PM2.5, PM2.5–10, PM10 as well as NO2 and NOx were estimated using the Land Use Regression model. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a median follow-up of 11.7 years, 1872 incident ulcerative colitis and 865 incident Crohn’s disease cases were identified among 455,210 IBD-free participants. HRs (95% CIs) of ulcerative colitis associated with each 1 interquartile range (IQR) increase in PM2.5, PM2.5–10, PM10, NO2, and NOx were 1.06 (1.01, 1.12), 1.03 (0.99, 1.08), 1.09 (1.03, 1.16), 1.12 (1.07, 1.19), and 1.07 (1.02, 1.12), respectively. The associations between all the air pollutants and risk of Crohn’s disease were null. Smoking status and sex appeared to respectively modify the associations between some air pollutants and risk of ulcerative colitis and Crohn’s disease. Conclusion: Long-term exposure to various air pollutants was associated with the risk of incident ulcerative colitis but not Crohn’s disease, highlighting the importance of developing environmental health strategy to reduce the burden of ulcerative colitis. |
| first_indexed | 2024-04-12T06:10:49Z |
| format | Article |
| id | doaj.art-b14e4099cb6a4362bb3069f6d7013969 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-12T06:10:49Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-b14e4099cb6a4362bb3069f6d70139692022-12-22T03:44:42ZengElsevierEcotoxicology and Environmental Safety0147-65132022-09-01242113835Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adultsFu-Rong Li0Ke-Yi Wu1Wei-Dong Fan2Guo-Chong Chen3Haili Tian4Xian-Bo Wu5School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USASchool of Kinesiology, Shanghai University of Sport, Shanghai, China; Correspondence to: School of Kinesiology, Shanghai University of Sport, Shanghai, China.Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China; Correspondence to: Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong 510515, China.Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant. Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Crohn’s disease, two subtypes of IBD, among middle and old aged adults in the UK. We also explored potential susceptible subgroups. Methods: We used data from the UK Biobank study. Information on air pollution, including PM2.5, PM2.5–10, PM10 as well as NO2 and NOx were estimated using the Land Use Regression model. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a median follow-up of 11.7 years, 1872 incident ulcerative colitis and 865 incident Crohn’s disease cases were identified among 455,210 IBD-free participants. HRs (95% CIs) of ulcerative colitis associated with each 1 interquartile range (IQR) increase in PM2.5, PM2.5–10, PM10, NO2, and NOx were 1.06 (1.01, 1.12), 1.03 (0.99, 1.08), 1.09 (1.03, 1.16), 1.12 (1.07, 1.19), and 1.07 (1.02, 1.12), respectively. The associations between all the air pollutants and risk of Crohn’s disease were null. Smoking status and sex appeared to respectively modify the associations between some air pollutants and risk of ulcerative colitis and Crohn’s disease. Conclusion: Long-term exposure to various air pollutants was associated with the risk of incident ulcerative colitis but not Crohn’s disease, highlighting the importance of developing environmental health strategy to reduce the burden of ulcerative colitis.http://www.sciencedirect.com/science/article/pii/S0147651322006753Inflammatory bowel diseaseAir pollutionEpidemiology |
| spellingShingle | Fu-Rong Li Ke-Yi Wu Wei-Dong Fan Guo-Chong Chen Haili Tian Xian-Bo Wu Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults Ecotoxicology and Environmental Safety Inflammatory bowel disease Air pollution Epidemiology |
| title | Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| title_full | Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| title_fullStr | Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| title_full_unstemmed | Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| title_short | Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| title_sort | long term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults |
| topic | Inflammatory bowel disease Air pollution Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322006753 |
| work_keys_str_mv | AT furongli longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults AT keyiwu longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults AT weidongfan longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults AT guochongchen longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults AT hailitian longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults AT xianbowu longtermexposuretoairpollutionandriskofincidentinflammatoryboweldiseaseamongmiddleandoldagedadults |