The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases
The initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality of life of patients, concurrently exerting a considerable strain on both the economy and the social healthcare infrastructure. Exercise has demons...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1305208/full |
| _version_ | 1797365531695644672 |
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| author | Xuepeng Bian Qian Wang Yibing Wang Shujie Lou |
| author_facet | Xuepeng Bian Qian Wang Yibing Wang Shujie Lou |
| author_sort | Xuepeng Bian |
| collection | DOAJ |
| description | The initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality of life of patients, concurrently exerting a considerable strain on both the economy and the social healthcare infrastructure. Exercise has demonstrated its potential as both an effective preventive intervention and a rehabilitation approach among the emerging therapeutics targeting NDs. As the largest secretory organ, skeletal muscle possesses the capacity to secrete myokines, and these myokines can partially improve the prognosis of NDs by mediating the muscle-brain axis. Besides the well-studied exerkines, which are secreted by skeletal muscle during exercise that pivotally exert their beneficial function, the physiological function of novel exerkines, e.g., apelin, kynurenic acid (KYNA), and lactate have been underappreciated previously. Herein, this review discusses the roles of these novel exerkines and their mechanisms in regulating the progression and improvement of NDs, especially the significance of their functions in improving NDs’ prognoses through exercise. Furthermore, several myokines with potential implications in ameliorating ND progression are proposed as the future direction for investigation. Elucidation of the function of exerkines secreted by skeletal muscle in the regulation of NDs advances the understanding of its pathogenesis and facilitates the development of therapeutics that intervene in these processes to cure NDs. |
| first_indexed | 2024-03-08T16:50:18Z |
| format | Article |
| id | doaj.art-b14f03ddd29549aa8fe0b955a86f7317 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-08T16:50:18Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-b14f03ddd29549aa8fe0b955a86f73172024-01-05T04:49:09ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992024-01-011610.3389/fnmol.2023.13052081305208The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseasesXuepeng Bian0Qian Wang1Yibing Wang2Shujie Lou3School of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaInstitute for Health and Sport, Victoria University, Melbourne, VIC, AustraliaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaThe initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality of life of patients, concurrently exerting a considerable strain on both the economy and the social healthcare infrastructure. Exercise has demonstrated its potential as both an effective preventive intervention and a rehabilitation approach among the emerging therapeutics targeting NDs. As the largest secretory organ, skeletal muscle possesses the capacity to secrete myokines, and these myokines can partially improve the prognosis of NDs by mediating the muscle-brain axis. Besides the well-studied exerkines, which are secreted by skeletal muscle during exercise that pivotally exert their beneficial function, the physiological function of novel exerkines, e.g., apelin, kynurenic acid (KYNA), and lactate have been underappreciated previously. Herein, this review discusses the roles of these novel exerkines and their mechanisms in regulating the progression and improvement of NDs, especially the significance of their functions in improving NDs’ prognoses through exercise. Furthermore, several myokines with potential implications in ameliorating ND progression are proposed as the future direction for investigation. Elucidation of the function of exerkines secreted by skeletal muscle in the regulation of NDs advances the understanding of its pathogenesis and facilitates the development of therapeutics that intervene in these processes to cure NDs.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1305208/fullexercisemyokineneurodegenerative diseaseapelinlactateKYNA |
| spellingShingle | Xuepeng Bian Qian Wang Yibing Wang Shujie Lou The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases Frontiers in Molecular Neuroscience exercise myokine neurodegenerative disease apelin lactate KYNA |
| title | The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| title_full | The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| title_fullStr | The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| title_full_unstemmed | The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| title_short | The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| title_sort | function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases |
| topic | exercise myokine neurodegenerative disease apelin lactate KYNA |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1305208/full |
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