Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain
The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate. Frequency and clinical features of symptomatic epilepsy, the reaction of AMPA recepto...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2013-12-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| Subjects: | |
| Online Access: | https://www.sci-notes.ru/jour/article/view/205 |
| _version_ | 1797702232785813504 |
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| author | V. N. Ochkolyas A. F. Gurchin A. A. Skoromets A. V. Kostyukevich |
| author_facet | V. N. Ochkolyas A. F. Gurchin A. A. Skoromets A. V. Kostyukevich |
| author_sort | V. N. Ochkolyas |
| collection | DOAJ |
| description | The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate. Frequency and clinical features of symptomatic epilepsy, the reaction of AMPA receptors of glutamate depending on localization and degree of malignance and features of clinical course of the disease wereinvestigated as well. Marked increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate was noticed in the patients with gliomas associated with epileptic syndrome. Maximal level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate seen under the effect of the tumor on the frontal and temporal lobels. |
| first_indexed | 2024-03-12T04:47:13Z |
| format | Article |
| id | doaj.art-b14f6246c9434d4185c714ed6f1b2fcf |
| institution | Directory Open Access Journal |
| issn | 1607-4181 |
| language | Russian |
| last_indexed | 2024-03-12T04:47:13Z |
| publishDate | 2013-12-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-b14f6246c9434d4185c714ed6f1b2fcf2023-09-03T09:26:55ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812013-12-01204737610.24884/1607-4181-2013-20-4-73-76202Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brainV. N. Ochkolyas0A. F. Gurchin1A. A. Skoromets2A. V. Kostyukevich3Pavlov First State Medical University of St. Petersburg; Institute of the Human Brain, Russian Academy of Sciences, St. PetersburgPavlov First State Medical University of St. Petersburg; Institute of the Human Brain, Russian Academy of Sciences, St. PetersburgPavlov First State Medical University of St. Petersburg; Institute of the Human Brain, Russian Academy of Sciences, St. PetersburgPavlov First State Medical University of St. Petersburg; Institute of the Human Brain, Russian Academy of Sciences, St. PetersburgThe authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate. Frequency and clinical features of symptomatic epilepsy, the reaction of AMPA receptors of glutamate depending on localization and degree of malignance and features of clinical course of the disease wereinvestigated as well. Marked increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate was noticed in the patients with gliomas associated with epileptic syndrome. Maximal level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate seen under the effect of the tumor on the frontal and temporal lobels.https://www.sci-notes.ru/jour/article/view/205gliomaepileptic syndromeampa glutamate receptors. |
| spellingShingle | V. N. Ochkolyas A. F. Gurchin A. A. Skoromets A. V. Kostyukevich Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова glioma epileptic syndrome ampa glutamate receptors. |
| title | Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| title_full | Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| title_fullStr | Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| title_full_unstemmed | Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| title_short | Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| title_sort | epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to glur1 subunit of ampa glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain |
| topic | glioma epileptic syndrome ampa glutamate receptors. |
| url | https://www.sci-notes.ru/jour/article/view/205 |
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