Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/4/290 |
| _version_ | 1827695366124863488 |
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| author | Gianluca Ingrosso Simonetta Saldi Simona Marani Alicia Y. W. Wong Matteo Bertelli Cynthia Aristei Teresa Zelante |
| author_facet | Gianluca Ingrosso Simonetta Saldi Simona Marani Alicia Y. W. Wong Matteo Bertelli Cynthia Aristei Teresa Zelante |
| author_sort | Gianluca Ingrosso |
| collection | DOAJ |
| description | Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i>Candida albicans</i>, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. |
| first_indexed | 2024-03-10T12:24:21Z |
| format | Article |
| id | doaj.art-b14f655f266948a4b167131c2bba2084 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T12:24:21Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b14f655f266948a4b167131c2bba20842023-11-21T15:09:47ZengMDPI AGJournal of Fungi2309-608X2021-04-017429010.3390/jof7040290Breakdown of Symbiosis in Radiation-Induced Oral MucositisGianluca Ingrosso0Simonetta Saldi1Simona Marani2Alicia Y. W. Wong3Matteo Bertelli4Cynthia Aristei5Teresa Zelante6Radiation Oncology Section, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, ItalyRadiation Oncology Section, Perugia General Hospital, 06129 Perugia, ItalyRadiation Oncology Section, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, ItalyDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, 141 86 Stockholm, SwedenMAGI Group, 25010 San Felice del Benaco (BS), ItalyRadiation Oncology Section, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, ItalyPathology Section, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, ItalyOral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i>Candida albicans</i>, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy.https://www.mdpi.com/2309-608X/7/4/290oral mucositis<i>Candida albicans</i>microbiotafungal infectionslactobacilliradiation therapy |
| spellingShingle | Gianluca Ingrosso Simonetta Saldi Simona Marani Alicia Y. W. Wong Matteo Bertelli Cynthia Aristei Teresa Zelante Breakdown of Symbiosis in Radiation-Induced Oral Mucositis Journal of Fungi oral mucositis <i>Candida albicans</i> microbiota fungal infections lactobacilli radiation therapy |
| title | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
| title_full | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
| title_fullStr | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
| title_full_unstemmed | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
| title_short | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
| title_sort | breakdown of symbiosis in radiation induced oral mucositis |
| topic | oral mucositis <i>Candida albicans</i> microbiota fungal infections lactobacilli radiation therapy |
| url | https://www.mdpi.com/2309-608X/7/4/290 |
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