Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases
Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Mitochondria are the main cellular energy powerhouses, supplying most of A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/1/150 |
| _version_ | 1797711535487844352 |
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| author | Qian Cai Yu Young Jeong |
| author_facet | Qian Cai Yu Young Jeong |
| author_sort | Qian Cai |
| collection | DOAJ |
| description | Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer’s disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders. |
| first_indexed | 2024-03-12T07:07:25Z |
| format | Article |
| id | doaj.art-b151255a033741a09de263dee3fec91a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:07:25Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b151255a033741a09de263dee3fec91a2023-09-02T23:19:42ZengMDPI AGCells2073-44092020-01-019115010.3390/cells9010150cells9010150Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative DiseasesQian Cai0Yu Young Jeong1Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USADepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USAMitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer’s disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders.https://www.mdpi.com/2073-4409/9/1/150mitophagymitophagosomelysosomemitochondrial dynamicsmitochondrial quality controlalzheimer’s diseaseparkinson’s diseasehuntington’s diseaseamyotrophic lateral sclerosisaging |
| spellingShingle | Qian Cai Yu Young Jeong Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases Cells mitophagy mitophagosome lysosome mitochondrial dynamics mitochondrial quality control alzheimer’s disease parkinson’s disease huntington’s disease amyotrophic lateral sclerosis aging |
| title | Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases |
| title_full | Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases |
| title_fullStr | Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases |
| title_full_unstemmed | Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases |
| title_short | Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases |
| title_sort | mitophagy in alzheimer s disease and other age related neurodegenerative diseases |
| topic | mitophagy mitophagosome lysosome mitochondrial dynamics mitochondrial quality control alzheimer’s disease parkinson’s disease huntington’s disease amyotrophic lateral sclerosis aging |
| url | https://www.mdpi.com/2073-4409/9/1/150 |
| work_keys_str_mv | AT qiancai mitophagyinalzheimersdiseaseandotheragerelatedneurodegenerativediseases AT yuyoungjeong mitophagyinalzheimersdiseaseandotheragerelatedneurodegenerativediseases |