Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer
The paper is concerned with an important stage of the technology development of the third generation photosensitizer for photodynamic therapy of cancer with 800 nm absorption band. An important requirement of a process chain of obtaining of bacteriochlorin p N-ethoxycycloimide O-ethyloxime methyl es...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2013-04-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/639 |
| Summary: | The paper is concerned with an important stage of the technology development of the third generation photosensitizer for photodynamic therapy of cancer with 800 nm absorption band. An important requirement of a process chain of obtaining of bacteriochlorin p N-ethoxycycloimide O-ethyloxime methyl ester is organization of reliable and efficient quality control of the original Rhodobacter capsulate biomass, its moisture content, concentration of the isolated bacteriochlorophyll a and conversion of the latter into bacteriopurpurin and its chemical modification into the target product along with the control of the intermediate products at every stage of the manufacturing process. When organizing the production, duration of the tests at each step of the process, accuracy and reliability of the quality monitoring should be the determining criteria. On the basis of functional modeling methodology there was created a complex of models in IDEF0 notation, describing production technology and quality control procedure of bacteriochlorin p N-ethoxycycloimide O-ethyloxime. |
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| ISSN: | 2410-6593 2686-7575 |