Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer
The paper is concerned with an important stage of the technology development of the third generation photosensitizer for photodynamic therapy of cancer with 800 nm absorption band. An important requirement of a process chain of obtaining of bacteriochlorin p N-ethoxycycloimide O-ethyloxime methyl es...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2013-04-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/639 |
| _version_ | 1826565798616891392 |
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| author | N. A. Mironova E.V. Burlyaeva Burlyaeva |
| author_facet | N. A. Mironova E.V. Burlyaeva Burlyaeva |
| author_sort | N. A. Mironova |
| collection | DOAJ |
| description | The paper is concerned with an important stage of the technology development of the third generation photosensitizer for photodynamic therapy of cancer with 800 nm absorption band. An important requirement of a process chain of obtaining of bacteriochlorin p N-ethoxycycloimide O-ethyloxime methyl ester is organization of reliable and efficient quality control of the original Rhodobacter capsulate biomass, its moisture content, concentration of the isolated bacteriochlorophyll a and conversion of the latter into bacteriopurpurin and its chemical modification into the target product along with the control of the intermediate products at every stage of the manufacturing process. When organizing the production, duration of the tests at each step of the process, accuracy and reliability of the quality monitoring should be the determining criteria. On the basis of functional modeling methodology there was created a complex of models in IDEF0 notation, describing production technology and quality control procedure of bacteriochlorin p N-ethoxycycloimide O-ethyloxime. |
| first_indexed | 2024-04-10T03:30:04Z |
| format | Article |
| id | doaj.art-b1530d345df14ce8b13d5e529c065304 |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2025-03-14T10:41:29Z |
| publishDate | 2013-04-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-b1530d345df14ce8b13d5e529c0653042025-03-02T10:57:30ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752013-04-018295100633Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancerN. A. Mironova0E.V. Burlyaeva Burlyaeva1M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571The paper is concerned with an important stage of the technology development of the third generation photosensitizer for photodynamic therapy of cancer with 800 nm absorption band. An important requirement of a process chain of obtaining of bacteriochlorin p N-ethoxycycloimide O-ethyloxime methyl ester is organization of reliable and efficient quality control of the original Rhodobacter capsulate biomass, its moisture content, concentration of the isolated bacteriochlorophyll a and conversion of the latter into bacteriopurpurin and its chemical modification into the target product along with the control of the intermediate products at every stage of the manufacturing process. When organizing the production, duration of the tests at each step of the process, accuracy and reliability of the quality monitoring should be the determining criteria. On the basis of functional modeling methodology there was created a complex of models in IDEF0 notation, describing production technology and quality control procedure of bacteriochlorin p N-ethoxycycloimide O-ethyloxime.https://www.finechem-mirea.ru/jour/article/view/639system analysis, functional modeling, decomposition, third generation photosensitizers, photodynamic therapy |
| spellingShingle | N. A. Mironova E.V. Burlyaeva Burlyaeva Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer Тонкие химические технологии system analysis, functional modeling, decomposition, third generation photosensitizers, photodynamic therapy |
| title | Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer |
| title_full | Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer |
| title_fullStr | Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer |
| title_full_unstemmed | Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer |
| title_short | Functional simulation of production of a new 3-rd generation photosensitizer for photodynamic therapy of cancer |
| title_sort | functional simulation of production of a new 3 rd generation photosensitizer for photodynamic therapy of cancer |
| topic | system analysis, functional modeling, decomposition, third generation photosensitizers, photodynamic therapy |
| url | https://www.finechem-mirea.ru/jour/article/view/639 |
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