Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells

Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells

In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin complexes were considered. We demonstrate for the...

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Bibliographic Details
Main Authors: Terenzio Congiu, Mawadda Alghrably, Abdul-Hamid Emwas, Lukasz Jaremko, Joanna I. Lachowicz, Marco Piludu, Monica Piras, Gavino Faa, Giuseppina Pichiri, Mariusz Jaremko, Pierpaolo Coni
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
diabetic nephropathy (DN)
metformin
copper
human islet amyloid polypeptide (hIAPP)
metal complexes
Online Access:https://www.mdpi.com/1999-4923/13/6/830

Internet

https://www.mdpi.com/1999-4923/13/6/830

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