The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

Abstract The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), a member of the MYC oncogene family, are critically involved in brain development. Both genes are...

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Bibliographic Details
Main Authors: Melanie Schoof, Gefion Dorothea Epplen, Carolin Walter, Annika Ballast, Dörthe Holdhof, Carolin Göbel, Sina Neyazi, Julian Varghese, Thomas Karl Albert, Kornelius Kerl, Ulrich Schüller
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00481-3

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