DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture of two tubular...

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Bibliographic Details
Main Authors: Simona Hankeova, Jakub Salplachta, Tomas Zikmund, Michaela Kavkova, Noémi Van Hul, Adam Brinek, Veronika Smekalova, Jakub Laznovsky, Feven Dawit, Josef Jaros, Vítězslav Bryja, Urban Lendahl, Ewa Ellis, Antal Nemeth, Björn Fischler, Edouard Hannezo, Jozef Kaiser, Emma Rachel Andersson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
Alagille syndrome
cholangiopathy
vasculature
MicroCT
resin
Online Access:https://elifesciences.org/articles/60916

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