Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study
Objective: In this study, we aimed to investigate whether there would be any improvement in symptoms of overactive bladder (OAB) after migraine prophylaxis in patients with chronic migraine (CM) and OAB. Materials and Methods: The study group consisted of women aged 19 to 64 years diagnosed as CM...
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| Format: | Article |
| Language: | English |
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Ekrem Güner
2024-01-01
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| Series: | Grand Journal of Urology |
| Subjects: | |
| Online Access: | https://grandjournalofurology.com/uploads/pdf/pdf_GJU_98.pdf |
| _version_ | 1797341298388107264 |
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| author | Sinan Eliaçık Aykut Başer Funda Uysal Tan |
| author_facet | Sinan Eliaçık Aykut Başer Funda Uysal Tan |
| author_sort | Sinan Eliaçık |
| collection | DOAJ |
| description | Objective: In this study, we aimed to investigate whether there would be any improvement in symptoms of overactive bladder (OAB) after migraine prophylaxis in patients with chronic migraine (CM) and OAB.
Materials and Methods: The study group consisted of women aged 19 to 64 years diagnosed as CM according to current International Headache Society (IHS) criteria, and OAB using the OAB-V8 (Overactive Bladder Inquiry Form - V8) and ICIQ-SF (International Consultation on Incontinence Questionnaire Short Form) forms as well as clinical evaluation in the neurology and urology clinics. 63 patients informed and agreed to enter the study were started migraine prophylaxis and evaluated after 6 months for comparison of pre-treatment and post-treatment VPS (visual pain scale), OAB-V8, and the ICIQ-SF scores. Flunarizine, topiramate, venlafaxine and propranolol were used in the treatment of patients.
Results: The mean age of 63 women included in the study was 39.15 ± 8.74 (19-64) years. The mean Body Mass Index (BMI) of the patients was determined as 25.41 ± 3.64 (16.4-35.6) kg/m2. After migraine prophylaxis, VPS, OAB-V8 and ICIQ-SF scores decreased significantly in the entire patient group (p<0.05). Statistically significant changes were found in the values of VPS, OAB-V8 and ICIQ-SF in the topiramate or propranolol treated groups. In the flunarizine group, there was a significant statistical response in the VPS and OAB-V8 scores, while there were no significant changes in the ICIQ-SF and OAB-V8 scores in the venlafaxinetreated group.
Conclusion: The beneficial effect of migraine prophylaxis on OAB symptoms support somewhat shared etiopathogenesis for both disorders. However, the series is small and considering the involvement of multifactorial factors and complex physiopathology for both disorders further studies are necessary to reveal the underlying mechanisms and clinical impacts. |
| first_indexed | 2024-03-08T10:15:56Z |
| format | Article |
| id | doaj.art-b15b02f18c6541e7817f5b6b6a15dd70 |
| institution | Directory Open Access Journal |
| issn | 2757-7163 |
| language | English |
| last_indexed | 2024-03-08T10:15:56Z |
| publishDate | 2024-01-01 |
| publisher | Ekrem Güner |
| record_format | Article |
| series | Grand Journal of Urology |
| spelling | doaj.art-b15b02f18c6541e7817f5b6b6a15dd702024-01-28T20:57:44ZengEkrem GünerGrand Journal of Urology2757-71632024-01-014161110.5505/GJU.2024.61587Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational StudySinan Eliaçık0https://orcid.org/0000-0002-9415-0039Aykut Başer1https://orcid.org/0000-0003-0457-512XFunda Uysal Tan2https://orcid.org/0000-0002-3518-1935Department of Neurology, Hitit University School of Medicine, Corum, TürkiyeDepartment of Urology, Bandırma Onyedi Eylul University School of Medicine, Balikesir, TürkiyeDepartment of Neurology, Hitit University School of Medicine, Corum, TürkiyeObjective: In this study, we aimed to investigate whether there would be any improvement in symptoms of overactive bladder (OAB) after migraine prophylaxis in patients with chronic migraine (CM) and OAB. Materials and Methods: The study group consisted of women aged 19 to 64 years diagnosed as CM according to current International Headache Society (IHS) criteria, and OAB using the OAB-V8 (Overactive Bladder Inquiry Form - V8) and ICIQ-SF (International Consultation on Incontinence Questionnaire Short Form) forms as well as clinical evaluation in the neurology and urology clinics. 63 patients informed and agreed to enter the study were started migraine prophylaxis and evaluated after 6 months for comparison of pre-treatment and post-treatment VPS (visual pain scale), OAB-V8, and the ICIQ-SF scores. Flunarizine, topiramate, venlafaxine and propranolol were used in the treatment of patients. Results: The mean age of 63 women included in the study was 39.15 ± 8.74 (19-64) years. The mean Body Mass Index (BMI) of the patients was determined as 25.41 ± 3.64 (16.4-35.6) kg/m2. After migraine prophylaxis, VPS, OAB-V8 and ICIQ-SF scores decreased significantly in the entire patient group (p<0.05). Statistically significant changes were found in the values of VPS, OAB-V8 and ICIQ-SF in the topiramate or propranolol treated groups. In the flunarizine group, there was a significant statistical response in the VPS and OAB-V8 scores, while there were no significant changes in the ICIQ-SF and OAB-V8 scores in the venlafaxinetreated group. Conclusion: The beneficial effect of migraine prophylaxis on OAB symptoms support somewhat shared etiopathogenesis for both disorders. However, the series is small and considering the involvement of multifactorial factors and complex physiopathology for both disorders further studies are necessary to reveal the underlying mechanisms and clinical impacts.https://grandjournalofurology.com/uploads/pdf/pdf_GJU_98.pdfmigraineoveractive bladderincontinenceneurourologyfunctional urology |
| spellingShingle | Sinan Eliaçık Aykut Başer Funda Uysal Tan Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study Grand Journal of Urology migraine overactive bladder incontinence neurourology functional urology |
| title | Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study |
| title_full | Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study |
| title_fullStr | Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study |
| title_full_unstemmed | Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study |
| title_short | Does Migraine Prophylaxis Improve Overactive Bladder Symptoms? Prospective Observational Study |
| title_sort | does migraine prophylaxis improve overactive bladder symptoms prospective observational study |
| topic | migraine overactive bladder incontinence neurourology functional urology |
| url | https://grandjournalofurology.com/uploads/pdf/pdf_GJU_98.pdf |
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