Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis
Abstract Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2016-03-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579624 |
| _version_ | 1818926891587862528 |
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| author | Courtney Townsel Rebecca Keller Kendall Johnson Naveed Hussain Winston A. Campbell |
| author_facet | Courtney Townsel Rebecca Keller Kendall Johnson Naveed Hussain Winston A. Campbell |
| author_sort | Courtney Townsel |
| collection | DOAJ |
| description | Abstract
Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG.
Case A 29-year-old G3P1011 underwent cesarean birth of a male infant who developed oxygen desaturation requiring supplemental oxygen on day of life (DOL) 3. Based on the clinical course and after exclusion of other diagnoses, the infant was diagnosed with TNMG. Infant's condition improved spontaneously and he was weaned off supplemental oxygen and discharged home on DOL 12.
Conclusion Infants born to mothers with seronegative localized (ocular) MG are also susceptible to TNMG which may be late in onset. |
| first_indexed | 2024-12-20T03:04:19Z |
| format | Article |
| id | doaj.art-b15ce0e61c7c48e8b778c8b8010d779a |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-20T03:04:19Z |
| publishDate | 2016-03-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-b15ce0e61c7c48e8b778c8b8010d779a2022-12-21T19:55:39ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052016-03-010601e133e13610.1055/s-0036-1579624Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia GravisCourtney Townsel0Rebecca Keller1Kendall Johnson2Naveed Hussain3Winston A. Campbell4Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, ConnecticutDivision of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, ConnecticutDivision of Neonatology, Connecticut Children's Medical Center, Farmington, ConnecticutDivision of Neonatology, Connecticut Children's Medical Center, Farmington, ConnecticutDivision of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, ConnecticutAbstract Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG. Case A 29-year-old G3P1011 underwent cesarean birth of a male infant who developed oxygen desaturation requiring supplemental oxygen on day of life (DOL) 3. Based on the clinical course and after exclusion of other diagnoses, the infant was diagnosed with TNMG. Infant's condition improved spontaneously and he was weaned off supplemental oxygen and discharged home on DOL 12. Conclusion Infants born to mothers with seronegative localized (ocular) MG are also susceptible to TNMG which may be late in onset.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579624ocular myasthenia gravispregnancytransient neonatal myasthenia gravis |
| spellingShingle | Courtney Townsel Rebecca Keller Kendall Johnson Naveed Hussain Winston A. Campbell Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis American Journal of Perinatology Reports ocular myasthenia gravis pregnancy transient neonatal myasthenia gravis |
| title | Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis |
| title_full | Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis |
| title_fullStr | Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis |
| title_full_unstemmed | Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis |
| title_short | Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis |
| title_sort | seronegative maternal ocular myasthenia gravis and delayed transient neonatal myasthenia gravis |
| topic | ocular myasthenia gravis pregnancy transient neonatal myasthenia gravis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579624 |
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