Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis

This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroiditis (AIT) at euthyroid and hypothyroid conditions. Contents of CD95+, annexin V-presenting (apoptotic) cells and TNF-α in blood were analyzed. It was shown, that altered regulation...

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Main Authors: M. I. Sheremet, V. O. Shidlovsky, L. P. Sidorchuk
Format: Article
Language:English
Published: Kazimierz Wielki University 2017-07-01
Series:Journal of Education, Health and Sport
Subjects:
Online Access:https://apcz.umk.pl/JEHS/article/view/24345
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author M. I. Sheremet
V. O. Shidlovsky
L. P. Sidorchuk
author_facet M. I. Sheremet
V. O. Shidlovsky
L. P. Sidorchuk
author_sort M. I. Sheremet
collection DOAJ
description This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroiditis (AIT) at euthyroid and hypothyroid conditions. Contents of CD95+, annexin V-presenting (apoptotic) cells and TNF-α in blood were analyzed. It was shown, that altered regulation of programmed lymphocyte death in autoimmune thyroid disorders is demonstrated by increased content of TNF-α, INF-γ and CD95+ lymphocytes, being accompanied by decreased numbers of apoptotic cells in blood. After the complex treatment, positive dynamics of the disturbed parameters of the immune status was noted, first of all, the normalization of the disturbed balance of the subpopulation of apoptotic T-lymphocytes and antibodies to thyroglobulin and thyroid peroxidase, decrease in the content of cytokines, and returning to the limit of normal values of thyroid hormones levels. The application of the proposed therapeutic tactics and the diagnostic and treatment complex allowed to reduce the probability of progression of autoimmune and oxidative processes in the thyroid residue (by 79.3%), to exclude the probability of the development of relapses of the nodal goiter on the background of autoimmune thyroiditis.
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spelling doaj.art-b15e7cf5bc254cb3a6e6968563ac131f2022-12-22T01:49:13ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-07-0177Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditisM. I. Sheremet0V. O. Shidlovsky1L. P. Sidorchuk2Department of Higher Education of Ukraine "Bukovina State Medical University"Department of Higher Education of Ukraine "Ternopil State Medical University"Department of Higher Education of Ukraine "Bukovina State Medical University" This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroiditis (AIT) at euthyroid and hypothyroid conditions. Contents of CD95+, annexin V-presenting (apoptotic) cells and TNF-α in blood were analyzed. It was shown, that altered regulation of programmed lymphocyte death in autoimmune thyroid disorders is demonstrated by increased content of TNF-α, INF-γ and CD95+ lymphocytes, being accompanied by decreased numbers of apoptotic cells in blood. After the complex treatment, positive dynamics of the disturbed parameters of the immune status was noted, first of all, the normalization of the disturbed balance of the subpopulation of apoptotic T-lymphocytes and antibodies to thyroglobulin and thyroid peroxidase, decrease in the content of cytokines, and returning to the limit of normal values of thyroid hormones levels. The application of the proposed therapeutic tactics and the diagnostic and treatment complex allowed to reduce the probability of progression of autoimmune and oxidative processes in the thyroid residue (by 79.3%), to exclude the probability of the development of relapses of the nodal goiter on the background of autoimmune thyroiditis. https://apcz.umk.pl/JEHS/article/view/24345autoimmune thyroiditisapoptosisanneksin V testCD95TNF-αINF-γ
spellingShingle M. I. Sheremet
V. O. Shidlovsky
L. P. Sidorchuk
Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
Journal of Education, Health and Sport
autoimmune thyroiditis
apoptosis
anneksin V test
CD95
TNF-α
INF-γ
title Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
title_full Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
title_fullStr Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
title_full_unstemmed Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
title_short Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
title_sort prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
topic autoimmune thyroiditis
apoptosis
anneksin V test
CD95
TNF-α
INF-γ
url https://apcz.umk.pl/JEHS/article/view/24345
work_keys_str_mv AT misheremet preventionofcomplicationsinremoteperiodafteroperationaltreatmentofpatientswithnodulargoiteronbackgroundautoimmunethyroiditis
AT voshidlovsky preventionofcomplicationsinremoteperiodafteroperationaltreatmentofpatientswithnodulargoiteronbackgroundautoimmunethyroiditis
AT lpsidorchuk preventionofcomplicationsinremoteperiodafteroperationaltreatmentofpatientswithnodulargoiteronbackgroundautoimmunethyroiditis