Tracheal Tissue Engineering: Principles and State of the Art
Patients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materia...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/11/2/198 |
| _version_ | 1827344090369359872 |
|---|---|
| author | Marco Mammana Alessandro Bonis Vincenzo Verzeletti Andrea Dell’Amore Federico Rea |
| author_facet | Marco Mammana Alessandro Bonis Vincenzo Verzeletti Andrea Dell’Amore Federico Rea |
| author_sort | Marco Mammana |
| collection | DOAJ |
| description | Patients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materials, aortic allografts, transplantation, autologous tissue composites, and tissue engineering), each with advantages and drawbacks. Tracheal tissue engineering, on the other hand, aims at recreating a fully functional tracheal substitute, without the need for the patient to receive lifelong immunosuppression or endotracheal stents. Tissue engineering approaches involve the use of a scaffold, stem cells, and humoral signals. This paper reviews the main aspects of tracheal TE, starting from the choice of the scaffold to the type of stem cells that can be used to seed the scaffold, the methods for their culture and expansion, the issue of graft revascularization at the moment of in vivo implantation, and experimental models of tracheal research. Moreover, a critical insight on the state of the art of tracheal tissue engineering is also presented. |
| first_indexed | 2024-03-07T22:41:56Z |
| format | Article |
| id | doaj.art-b15eefebc3c743f6bee221d117aa7c2c |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-07T22:41:56Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-b15eefebc3c743f6bee221d117aa7c2c2024-02-23T15:08:05ZengMDPI AGBioengineering2306-53542024-02-0111219810.3390/bioengineering11020198Tracheal Tissue Engineering: Principles and State of the ArtMarco Mammana0Alessandro Bonis1Vincenzo Verzeletti2Andrea Dell’Amore3Federico Rea4Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyPatients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materials, aortic allografts, transplantation, autologous tissue composites, and tissue engineering), each with advantages and drawbacks. Tracheal tissue engineering, on the other hand, aims at recreating a fully functional tracheal substitute, without the need for the patient to receive lifelong immunosuppression or endotracheal stents. Tissue engineering approaches involve the use of a scaffold, stem cells, and humoral signals. This paper reviews the main aspects of tracheal TE, starting from the choice of the scaffold to the type of stem cells that can be used to seed the scaffold, the methods for their culture and expansion, the issue of graft revascularization at the moment of in vivo implantation, and experimental models of tracheal research. Moreover, a critical insight on the state of the art of tracheal tissue engineering is also presented.https://www.mdpi.com/2306-5354/11/2/198tracheatissue engineeringtransplantationstem cells |
| spellingShingle | Marco Mammana Alessandro Bonis Vincenzo Verzeletti Andrea Dell’Amore Federico Rea Tracheal Tissue Engineering: Principles and State of the Art Bioengineering trachea tissue engineering transplantation stem cells |
| title | Tracheal Tissue Engineering: Principles and State of the Art |
| title_full | Tracheal Tissue Engineering: Principles and State of the Art |
| title_fullStr | Tracheal Tissue Engineering: Principles and State of the Art |
| title_full_unstemmed | Tracheal Tissue Engineering: Principles and State of the Art |
| title_short | Tracheal Tissue Engineering: Principles and State of the Art |
| title_sort | tracheal tissue engineering principles and state of the art |
| topic | trachea tissue engineering transplantation stem cells |
| url | https://www.mdpi.com/2306-5354/11/2/198 |
| work_keys_str_mv | AT marcomammana trachealtissueengineeringprinciplesandstateoftheart AT alessandrobonis trachealtissueengineeringprinciplesandstateoftheart AT vincenzoverzeletti trachealtissueengineeringprinciplesandstateoftheart AT andreadellamore trachealtissueengineeringprinciplesandstateoftheart AT federicorea trachealtissueengineeringprinciplesandstateoftheart |