Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors
Such is the hypoxia in solid tumor that Ⅱ-type photodynamic therapy (PDT) has not yet achieved significantly satisfactory consequences. Despite the rapid advancement in nanotechnology-based PDT for alleviating the hypoxic tumor microenvironment, several challenges persist. These include inefficient...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523010341 |
| _version_ | 1797347837688676352 |
|---|---|
| author | Mingzhi Zhu Pei Wang Biaoqi Chen Linrong Shi Ruimin Long Shibin Wang Yuangang Liu |
| author_facet | Mingzhi Zhu Pei Wang Biaoqi Chen Linrong Shi Ruimin Long Shibin Wang Yuangang Liu |
| author_sort | Mingzhi Zhu |
| collection | DOAJ |
| description | Such is the hypoxia in solid tumor that Ⅱ-type photodynamic therapy (PDT) has not yet achieved significantly satisfactory consequences. Despite the rapid advancement in nanotechnology-based PDT for alleviating the hypoxic tumor microenvironment, several challenges persist. These include inefficient passive oxygen-supply mechanisms, low stability of oxygen-delivery nanosystems, and the complexity of their modification processes. To address these issues, we developed integrative nanoformulations (HHI NPs) by sequentially inserting biomacromolecule hemoglobin (Hb) and IR783 (photosensitizer) into hollow mesoporous Prussian blue (HPB NPs) through a straightforward and gentle diffusion method. Intriguingly, the resulting hybrid nanocomposites based on hollow mesoporous structure provided stability of biomacromolecule Hb, ensuring active and efficient oxygen delivery. In these nanosystems, HHI NPs equipped with high oxygen-carrying Hb efficiently generated reactive oxygen species over HepG2 cells cultured in hypoxic condition under NIR irradiation. Additionally, HPB NPs served not only as nanocarriers but also as photothermal agents exhibiting excellent photothermal conversion effects. which were beneficial for photothermal therapy (PTT) of cancer. HHI NPs co-loaded with Hb and IR783 not only actively relieved the hypoxic TME through the stable protection of the hollow structure from HPB NPs, but also achieve the significant synergistic therapy by combining PDT and PTT for tumor treatment. |
| first_indexed | 2024-03-08T11:54:42Z |
| format | Article |
| id | doaj.art-b160ee85c40d4b0bb85d7960095cbad4 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-08T11:54:42Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-b160ee85c40d4b0bb85d7960095cbad42024-01-24T05:16:46ZengElsevierMaterials & Design0264-12752024-01-01237112618Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumorsMingzhi Zhu0Pei Wang1Biaoqi Chen2Linrong Shi3Ruimin Long4Shibin Wang5Yuangang Liu6College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, ChinaSchool of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China; Corresponding authors at: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China (M. Zhu and Y. Liu). School of Stomatology, Nanchang University, Nanchang 330006, China (P. Wang).College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaInstitute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China; College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China; Corresponding authors at: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China (M. Zhu and Y. Liu). School of Stomatology, Nanchang University, Nanchang 330006, China (P. Wang).Such is the hypoxia in solid tumor that Ⅱ-type photodynamic therapy (PDT) has not yet achieved significantly satisfactory consequences. Despite the rapid advancement in nanotechnology-based PDT for alleviating the hypoxic tumor microenvironment, several challenges persist. These include inefficient passive oxygen-supply mechanisms, low stability of oxygen-delivery nanosystems, and the complexity of their modification processes. To address these issues, we developed integrative nanoformulations (HHI NPs) by sequentially inserting biomacromolecule hemoglobin (Hb) and IR783 (photosensitizer) into hollow mesoporous Prussian blue (HPB NPs) through a straightforward and gentle diffusion method. Intriguingly, the resulting hybrid nanocomposites based on hollow mesoporous structure provided stability of biomacromolecule Hb, ensuring active and efficient oxygen delivery. In these nanosystems, HHI NPs equipped with high oxygen-carrying Hb efficiently generated reactive oxygen species over HepG2 cells cultured in hypoxic condition under NIR irradiation. Additionally, HPB NPs served not only as nanocarriers but also as photothermal agents exhibiting excellent photothermal conversion effects. which were beneficial for photothermal therapy (PTT) of cancer. HHI NPs co-loaded with Hb and IR783 not only actively relieved the hypoxic TME through the stable protection of the hollow structure from HPB NPs, but also achieve the significant synergistic therapy by combining PDT and PTT for tumor treatment.http://www.sciencedirect.com/science/article/pii/S0264127523010341Hypoxic tumor microenvironmentReactive oxygen speciesHemoglobinPrussian blue nanoparticlesPhotothermal therapy |
| spellingShingle | Mingzhi Zhu Pei Wang Biaoqi Chen Linrong Shi Ruimin Long Shibin Wang Yuangang Liu Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors Materials & Design Hypoxic tumor microenvironment Reactive oxygen species Hemoglobin Prussian blue nanoparticles Photothermal therapy |
| title | Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors |
| title_full | Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors |
| title_fullStr | Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors |
| title_full_unstemmed | Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors |
| title_short | Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors |
| title_sort | active oxygenating hollow prussian blue nanosystems loaded with biomacromolecules for photodynamic photothermal therapy of cancer and alleviating hypoxic tumors |
| topic | Hypoxic tumor microenvironment Reactive oxygen species Hemoglobin Prussian blue nanoparticles Photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523010341 |
| work_keys_str_mv | AT mingzhizhu activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT peiwang activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT biaoqichen activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT linrongshi activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT ruiminlong activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT shibinwang activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors AT yuangangliu activeoxygenatinghollowprussianbluenanosystemsloadedwithbiomacromoleculesforphotodynamicphotothermaltherapyofcancerandalleviatinghypoxictumors |