Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the...

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Bibliographic Details
Main Authors: Huiliang Zhang, Nathan N Alder, Wang Wang, Hazel Szeto, David J Marcinek, Peter S Rabinovitch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
aging
mitochondria
SS-31
proton leak
cardiomyocyte
Online Access:https://elifesciences.org/articles/60827

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