Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems
Abstract Industrial development is the main cause of environmental pollution with various substances such as antibiotics and heavy metals. Many heavy metals with antimicrobial properties could contribute to antibiotic resistance and the emergence of antibiotic resistance genes due to the co-selectio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25272-5 |
| _version_ | 1811315185450745856 |
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| author | Majid Komijani Farnaz Eghbalpour Ebrahim Lari Nima Shaykh-Baygloo |
| author_facet | Majid Komijani Farnaz Eghbalpour Ebrahim Lari Nima Shaykh-Baygloo |
| author_sort | Majid Komijani |
| collection | DOAJ |
| description | Abstract Industrial development is the main cause of environmental pollution with various substances such as antibiotics and heavy metals. Many heavy metals with antimicrobial properties could contribute to antibiotic resistance and the emergence of antibiotic resistance genes due to the co-selection phenomenon. The aim of this study was to investigate the concurrent presence and correlation between several heavy metals and the erythromycin resistance genes in six aquatic ecosystems of Iran. Distribution and assessment of 11 erythromycin resistance genes were investigated using specific primers and online enrichment and triple-quadrupole LC–MS/MS. The concentration of heavy metals was measured using inductively coupled plasma atomic emission spectroscopy by Thermo electron corporation. Principal component analysis was performed to globally compare and to determine the similarities and differences among different aquatic ecosystems in different parts of the world in terms of the concentration of zinc and lead in their water. The results of the simple logistic regression analysis for the correlation between erythromycin resistance genes and heavy metals concentrations revealed the most significant correlation between erythromycin resistance genes and Pb concentration, followed by Co and Zn concentrations. |
| first_indexed | 2024-04-13T11:25:41Z |
| format | Article |
| id | doaj.art-b1626b68c6f841058e09dae083eadfce |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T11:25:41Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b1626b68c6f841058e09dae083eadfce2022-12-22T02:48:42ZengNature PortfolioScientific Reports2045-23222022-12-011211810.1038/s41598-022-25272-5Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystemsMajid Komijani0Farnaz Eghbalpour1Ebrahim Lari2Nima Shaykh-Baygloo3Department of Biology, Faculty of Science, Arak UniversityDepartment of Molecular Medicine, Golestan University of Medical SciencesDepartment of Biological Sciences, University of AlbertaDepartment of Biology, Faculty of Science, Urmia UniversityAbstract Industrial development is the main cause of environmental pollution with various substances such as antibiotics and heavy metals. Many heavy metals with antimicrobial properties could contribute to antibiotic resistance and the emergence of antibiotic resistance genes due to the co-selection phenomenon. The aim of this study was to investigate the concurrent presence and correlation between several heavy metals and the erythromycin resistance genes in six aquatic ecosystems of Iran. Distribution and assessment of 11 erythromycin resistance genes were investigated using specific primers and online enrichment and triple-quadrupole LC–MS/MS. The concentration of heavy metals was measured using inductively coupled plasma atomic emission spectroscopy by Thermo electron corporation. Principal component analysis was performed to globally compare and to determine the similarities and differences among different aquatic ecosystems in different parts of the world in terms of the concentration of zinc and lead in their water. The results of the simple logistic regression analysis for the correlation between erythromycin resistance genes and heavy metals concentrations revealed the most significant correlation between erythromycin resistance genes and Pb concentration, followed by Co and Zn concentrations.https://doi.org/10.1038/s41598-022-25272-5 |
| spellingShingle | Majid Komijani Farnaz Eghbalpour Ebrahim Lari Nima Shaykh-Baygloo Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems Scientific Reports |
| title | Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems |
| title_full | Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems |
| title_fullStr | Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems |
| title_full_unstemmed | Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems |
| title_short | Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems |
| title_sort | developing erythromycin resistance gene by heavy metals pb zn and co in aquatic ecosystems |
| url | https://doi.org/10.1038/s41598-022-25272-5 |
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