The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort
The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibr...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2018-04-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/2469 |
| _version_ | 1826997117268262912 |
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| author | Insa Korten Elisabeth Kieninger Sophie Yammine Nicolas Regamey Sylvia Nyilas Kathryn Ramsey Carmen Casaulta Philipp Latzin for the SCILD study group |
| author_facet | Insa Korten Elisabeth Kieninger Sophie Yammine Nicolas Regamey Sylvia Nyilas Kathryn Ramsey Carmen Casaulta Philipp Latzin for the SCILD study group |
| author_sort | Insa Korten |
| collection | DOAJ |
| description |
The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibrosis are recruited throughout Switzerland after diagnosis by new-born screening. It is the first European population-based prospective cohort study of infants with cystic fibrosis taking advantage of a nationwide new-born screening programme. The study was established in 2011 and recruitment is ongoing.
The cohort study is currently divided into three study phases (phase 1: diagnosis to age 1 year; phase 2: age 1 to 3 years; and phase 3: age 3 to 6 years). Study participants have weekly telephone interviews, weekly anterior nasal swab collection and two study visits in the first year of life. They also complete follow-up study visits at 3 and 6 years of age. Data for this study are derived from questionnaires, lung function measurements, telephone interviews, nasal swab material and magnetic resonance imaging.
To date, 70 infants have been recruited into the study and 56 have completed phase 1, including a baseline study visit at 6 weeks of age, weekly surveillance and a study visit at one year of age. More than 2500 data points on respiratory health and almost 2000 nasal samples have been collected. Phases 2 and 3 will commence in 2018.
The dataset of the SCILD cohort combines lung function data, the collection of environmental and sociodemographic factors, documentation of respiratory symptoms, and microbiological analyses. The design not only allows tracking of the cystic fibrosis lung disease independent of clinical status, but also surveillance of early disease prior to severe clinical symptoms.
This cohort profile provides details on the study design and summarizes the first published results of the SCILD cohort.
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| first_indexed | 2024-04-12T00:25:59Z |
| format | Article |
| id | doaj.art-b162708986a34825b019ba3350f15dfb |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:55:38Z |
| publishDate | 2018-04-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-b162708986a34825b019ba3350f15dfb2024-11-02T09:11:10ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972018-04-01148171810.4414/smw.2018.14618The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohortInsa Korten0Elisabeth Kieninger1Sophie Yammine2Nicolas Regamey3Sylvia Nyilas4Kathryn Ramsey5Carmen Casaulta6Philipp Latzin7for the SCILD study groupPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland; Department of Paediatrics, University Children's Hospital of Basel, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, SwitzerlandDivision of Respiratory Medicine, Children’s Hospital Lucerne, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, SwitzerlandPaediatric Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibrosis are recruited throughout Switzerland after diagnosis by new-born screening. It is the first European population-based prospective cohort study of infants with cystic fibrosis taking advantage of a nationwide new-born screening programme. The study was established in 2011 and recruitment is ongoing. The cohort study is currently divided into three study phases (phase 1: diagnosis to age 1 year; phase 2: age 1 to 3 years; and phase 3: age 3 to 6 years). Study participants have weekly telephone interviews, weekly anterior nasal swab collection and two study visits in the first year of life. They also complete follow-up study visits at 3 and 6 years of age. Data for this study are derived from questionnaires, lung function measurements, telephone interviews, nasal swab material and magnetic resonance imaging. To date, 70 infants have been recruited into the study and 56 have completed phase 1, including a baseline study visit at 6 weeks of age, weekly surveillance and a study visit at one year of age. More than 2500 data points on respiratory health and almost 2000 nasal samples have been collected. Phases 2 and 3 will commence in 2018. The dataset of the SCILD cohort combines lung function data, the collection of environmental and sociodemographic factors, documentation of respiratory symptoms, and microbiological analyses. The design not only allows tracking of the cystic fibrosis lung disease independent of clinical status, but also surveillance of early disease prior to severe clinical symptoms. This cohort profile provides details on the study design and summarizes the first published results of the SCILD cohort. https://www.smw.ch/index.php/smw/article/view/2469Swiss Cystic Fibrosis Infant Lung Development Cohort (SCILD)Cystic fibrosislongitudinal birth cohortcohort profile |
| spellingShingle | Insa Korten Elisabeth Kieninger Sophie Yammine Nicolas Regamey Sylvia Nyilas Kathryn Ramsey Carmen Casaulta Philipp Latzin for the SCILD study group The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort Swiss Medical Weekly Swiss Cystic Fibrosis Infant Lung Development Cohort (SCILD) Cystic fibrosis longitudinal birth cohort cohort profile |
| title | The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort |
| title_full | The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort |
| title_fullStr | The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort |
| title_full_unstemmed | The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort |
| title_short | The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort |
| title_sort | swiss cystic fibrosis infant lung development scild cohort |
| topic | Swiss Cystic Fibrosis Infant Lung Development Cohort (SCILD) Cystic fibrosis longitudinal birth cohort cohort profile |
| url | https://www.smw.ch/index.php/smw/article/view/2469 |
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