Tensile properties of human spinal dura mater and pericranium
Abstract Autologous pericranium is a promising dural graft material. An optimal graft should exhibit similar mechanical properties to the native dura, but the mechanical properties of human pericranium have not been characterized, and studies of the biomechanical performance of human spinal dura are...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer
2022-12-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-022-06704-0 |
| _version_ | 1797973797834326016 |
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| author | Sacha Cavelier Ryan D. Quarrington Claire F. Jones |
| author_facet | Sacha Cavelier Ryan D. Quarrington Claire F. Jones |
| author_sort | Sacha Cavelier |
| collection | DOAJ |
| description | Abstract Autologous pericranium is a promising dural graft material. An optimal graft should exhibit similar mechanical properties to the native dura, but the mechanical properties of human pericranium have not been characterized, and studies of the biomechanical performance of human spinal dura are limited. The primary aim of this study was to measure the tensile structural and material properties of the pericranium, in the longitudinal and circumferential directions, and of the dura in each spinal region (cervical, thoracic and lumbar) and in three directions (longitudinal anterior and posterior, and circumferential). The secondary aim was to determine corresponding constitutive stress–strain equations using a one-term Ogden model. A total of 146 specimens were tested from 7 cadavers. Linear regression models assessed the effect of tissue type, region, and orientation on the structural and material properties. Pericranium was isotropic, while spinal dura was anisotropic with higher stiffness and strength in the longitudinal than the circumferential direction. Pericranium had lower strength and modulus than spinal dura across all regions in the longitudinal direction but was stronger and stiffer than dura in the circumferential direction. Spinal dura and pericranium had similar strain at peak force, toe, and yield, across all regions and directions. Human pericranium exhibits isotropic mechanical behavior that lies between that of the longitudinal and circumferential spinal dura. Further studies are required to determine if pericranium grafts behave like native dura under in vivo loading conditions. The Ogden parameters reported may be used for computational modeling of the central nervous system. Graphical abstract |
| first_indexed | 2024-04-11T04:09:55Z |
| format | Article |
| id | doaj.art-b16317c6f96b48ed836ae5046f7dcac0 |
| institution | Directory Open Access Journal |
| issn | 1573-4838 |
| language | English |
| last_indexed | 2024-04-11T04:09:55Z |
| publishDate | 2022-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj.art-b16317c6f96b48ed836ae5046f7dcac02023-01-01T12:12:10ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382022-12-0134111110.1007/s10856-022-06704-0Tensile properties of human spinal dura mater and pericraniumSacha Cavelier0Ryan D. Quarrington1Claire F. Jones2Adelaide Spinal Research Group, Centre for Orthopaedic & Trauma Research, Adelaide Medical School, The University of AdelaideAdelaide Spinal Research Group, Centre for Orthopaedic & Trauma Research, Adelaide Medical School, The University of AdelaideAdelaide Spinal Research Group, Centre for Orthopaedic & Trauma Research, Adelaide Medical School, The University of AdelaideAbstract Autologous pericranium is a promising dural graft material. An optimal graft should exhibit similar mechanical properties to the native dura, but the mechanical properties of human pericranium have not been characterized, and studies of the biomechanical performance of human spinal dura are limited. The primary aim of this study was to measure the tensile structural and material properties of the pericranium, in the longitudinal and circumferential directions, and of the dura in each spinal region (cervical, thoracic and lumbar) and in three directions (longitudinal anterior and posterior, and circumferential). The secondary aim was to determine corresponding constitutive stress–strain equations using a one-term Ogden model. A total of 146 specimens were tested from 7 cadavers. Linear regression models assessed the effect of tissue type, region, and orientation on the structural and material properties. Pericranium was isotropic, while spinal dura was anisotropic with higher stiffness and strength in the longitudinal than the circumferential direction. Pericranium had lower strength and modulus than spinal dura across all regions in the longitudinal direction but was stronger and stiffer than dura in the circumferential direction. Spinal dura and pericranium had similar strain at peak force, toe, and yield, across all regions and directions. Human pericranium exhibits isotropic mechanical behavior that lies between that of the longitudinal and circumferential spinal dura. Further studies are required to determine if pericranium grafts behave like native dura under in vivo loading conditions. The Ogden parameters reported may be used for computational modeling of the central nervous system. Graphical abstracthttps://doi.org/10.1007/s10856-022-06704-0 |
| spellingShingle | Sacha Cavelier Ryan D. Quarrington Claire F. Jones Tensile properties of human spinal dura mater and pericranium Journal of Materials Science: Materials in Medicine |
| title | Tensile properties of human spinal dura mater and pericranium |
| title_full | Tensile properties of human spinal dura mater and pericranium |
| title_fullStr | Tensile properties of human spinal dura mater and pericranium |
| title_full_unstemmed | Tensile properties of human spinal dura mater and pericranium |
| title_short | Tensile properties of human spinal dura mater and pericranium |
| title_sort | tensile properties of human spinal dura mater and pericranium |
| url | https://doi.org/10.1007/s10856-022-06704-0 |
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