Brain blood vessel autoantibodies in patients with NMDA and GABAA receptor encephalitis: identification of unconventional Myosin-X as target antigen

Brain blood vessel autoantibodies in patients with NMDA and GABAA receptor encephalitis: identification of unconventional Myosin-X as target antigen

Introduction: The antibody repertoire from CSF-derived antibody-secreting cells and memory B-cells in patients with encephalitis contains a considerable number of antibodies that do not target the disease-defining autoantigen such as the GABA or NMDA receptors. This study focuses on the functional r...

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Bibliographic Details
Main Authors: Lucie Y. Li, Jakob Kreye, Malgorzata Burek, César Cordero-Gomez, Paula C. Barthel, Elisa Sánchez-Sendín, Hans-Christian Kornau, Dietmar Schmitz, Madeleine Scharf, Patrick Meybohm, S. Momsen Reincke, Harald Prüss, Markus Höltje
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood-brain barrier
autoimmunity
encephalitis
occludin
Myosin-X
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1077204/full

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