MPEP Attenuates Intrahepatic Fat Accumulation in Obese Mice

MPEP Attenuates Intrahepatic Fat Accumulation in Obese Mice

The blockade of metabotropic glutamate receptor type 5 (mGluR5) was previously found to reduce fat accumulation in HEPG2 cells. Here, we evaluated the effects of mGluR5 blockade in a mouse model of steatosis. Male <i>ob/ob</i> mice fed a high-fat diet were treated with MPEP or vehicle. A...

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Bibliographic Details
Main Authors:	Andrea Ferrigno, Marta Cagna, Oriana Bosco, Michelangelo Trucchi, Clarissa Berardo, Ferdinando Nicoletti, Mariapia Vairetti, Laura G. Di Pasqua
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	International Journal of Molecular Sciences
Subjects:	MPEP NAFLD NASH liver high-fat diet <i>ob/ob</i> mice
Online Access:	https://www.mdpi.com/1422-0067/24/7/6076

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