Importance of mir-411-5p in colorectal cancer
The abnormal expression of microRNAs (miRNAs) plays a key role in colorectal cancer (CRC). The present study attempted to identify the potential miRNA biomarkers of CRC due to the important role of microRNAs within the DLK1-DIO3 genomic region, especially the role of mir-411-5p in other cancers. Thi...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2018-02-01
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| Series: | Journal of Biological Research |
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| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/6511 |
| _version_ | 1818260714642472960 |
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| author | Alavieh Fateh Mohammad Ali Hosseinpour Feizi Reza Safaralizadeh Shirin Azarbarzin |
| author_facet | Alavieh Fateh Mohammad Ali Hosseinpour Feizi Reza Safaralizadeh Shirin Azarbarzin |
| author_sort | Alavieh Fateh |
| collection | DOAJ |
| description | The abnormal expression of microRNAs (miRNAs) plays a key role in colorectal cancer (CRC). The present study attempted to identify the potential miRNA biomarkers of CRC due to the important role of microRNAs within the DLK1-DIO3 genomic region, especially the role of mir-411-5p in other cancers. This prospective study characterized the contribution of mir-411-5p to CRC tumorigenesis. The Real-time quantitative reverse-transcription –polymerase chain reaction was used to examine miR-411-5p expression levels prospectively in 40 pairs of samples of CRC tissues and adjacent noncancerous tissues (>2 cm from cancer tissue). Also, the relationship between miR-411-5p expression levels and clinicopathological characteristics was explored. The capability of miR-411-5p to function as a tumor marker in CRC was also examined. MiR-411-5p was significantly downregulated in a group of CRC samples compared with matched noncancerous tissues. A receiver operating characteristic (ROC) curve also showed ROC area of 68% for miR-411-5p (P value=0.006) with 70% and 65% sensitivity and specificity, respectively. According to the survey results, miR-411-5p might be considered as a tumor marker in CRC and it might be a promising therapeutic option which may help prevent CRC. |
| first_indexed | 2024-12-12T18:35:44Z |
| format | Article |
| id | doaj.art-b16628442dbe45119f3fbfd5522c4d80 |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-12-12T18:35:44Z |
| publishDate | 2018-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-b16628442dbe45119f3fbfd5522c4d802022-12-22T00:15:47ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302018-02-0190210.4081/jbr.2017.65115580Importance of mir-411-5p in colorectal cancerAlavieh Fateh0Mohammad Ali Hosseinpour Feizi1Reza Safaralizadeh2Shirin Azarbarzin3Department of Animal Biology, Faculty of Natural Science, University of TabrizDepartment of Animal Biology, Faculty of Natural Science, University of TabrizDepartment of Animal Biology, Faculty of Natural Science, University of TabrizDepartment of Animal Biology, Faculty of Natural Science, University of TabrizThe abnormal expression of microRNAs (miRNAs) plays a key role in colorectal cancer (CRC). The present study attempted to identify the potential miRNA biomarkers of CRC due to the important role of microRNAs within the DLK1-DIO3 genomic region, especially the role of mir-411-5p in other cancers. This prospective study characterized the contribution of mir-411-5p to CRC tumorigenesis. The Real-time quantitative reverse-transcription –polymerase chain reaction was used to examine miR-411-5p expression levels prospectively in 40 pairs of samples of CRC tissues and adjacent noncancerous tissues (>2 cm from cancer tissue). Also, the relationship between miR-411-5p expression levels and clinicopathological characteristics was explored. The capability of miR-411-5p to function as a tumor marker in CRC was also examined. MiR-411-5p was significantly downregulated in a group of CRC samples compared with matched noncancerous tissues. A receiver operating characteristic (ROC) curve also showed ROC area of 68% for miR-411-5p (P value=0.006) with 70% and 65% sensitivity and specificity, respectively. According to the survey results, miR-411-5p might be considered as a tumor marker in CRC and it might be a promising therapeutic option which may help prevent CRC.http://www.pagepressjournals.org/index.php/jbr/article/view/6511colorectal cancer, biomarker, microRNA, miR-411-5p |
| spellingShingle | Alavieh Fateh Mohammad Ali Hosseinpour Feizi Reza Safaralizadeh Shirin Azarbarzin Importance of mir-411-5p in colorectal cancer Journal of Biological Research colorectal cancer, biomarker, microRNA, miR-411-5p |
| title | Importance of mir-411-5p in colorectal cancer |
| title_full | Importance of mir-411-5p in colorectal cancer |
| title_fullStr | Importance of mir-411-5p in colorectal cancer |
| title_full_unstemmed | Importance of mir-411-5p in colorectal cancer |
| title_short | Importance of mir-411-5p in colorectal cancer |
| title_sort | importance of mir 411 5p in colorectal cancer |
| topic | colorectal cancer, biomarker, microRNA, miR-411-5p |
| url | http://www.pagepressjournals.org/index.php/jbr/article/view/6511 |
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