Comparing the Effect of Room Air versus Commercially Available Oxygen for the Resuscitation of Asphyxiated Neonates in Kabul City: A Randomised Clinical Trial
Introduction: Perinatal asphyxia is one of the leading causes of neonatal death in Afghanistan. Recent recommendation has accepted room air as preferred therapy in the resuscitation of asphyxiated term neonates. Since the quality of air is poor in Kabul city so a study was needed to assess its e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2019-07-01
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| Series: | Indian Journal of Neonatal Medicine and Research |
| Subjects: | |
| Online Access: | http://www.ijnmr.net/articles/PDF/2255/42701_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdf |
| Summary: | Introduction: Perinatal asphyxia is one of the leading causes
of neonatal death in Afghanistan. Recent recommendation has
accepted room air as preferred therapy in the resuscitation of
asphyxiated term neonates. Since the quality of air is poor in
Kabul city so a study was needed to assess its efficacy in the
resuscitation of neonates.
Aim: To evaluate the effectiveness of room air versus
commercially available oxygen for the resuscitation of
asphyxiated term and preterm neonates.
Materials and Methods: This study was a randomised clinical
trial conducted at Neonatology ward of Malalai Hospital in
Kabul city, Afghanistan. Total 300 neonates of 30-41 weeks
gestation diagnosed as severe perinatal asphyxia were
randomly resuscitated with either room air or commercially
available oxygen. The clinical parameters were the Apgar
score, oxygen saturation and neonatal mortality percentage.
Statically analysis was performed by SPSS 20.
Results: One hundred and fifty neonates in the room air
group and 150 neonates in commercially available oxygen
group were investigated. The term neonate percentage
was 76% and 75.3% in the room air and oxygen group
respectively. Term neonates resuscitated with room air
had obtained higher mean oxygen saturation (83.4±14.9,
p=0.001) than oxygen (77.1±13.1, p=0.001) at 5 minute of
birth. Median Apgar score was the same in both groups (5,
p=0.001). The difference of mortality during hospital stay in
both groups was not statistically significant (5.26% vs 7%,
p=0.59). Mean oxygen saturation in preterm newborn babies
were 80.58±15.62 and 78.41±11.91 with p=0.22, respectively
in both groups. Median Apgar score in room air was 6 and in
oxygen group was 5 with p=0.33. Preterm infant also showed
non-significant difference of mortality during hospital stay in
both groups (11.1% vs 18.9%, p=0.5).
Conclusion: Despite poor air quality in Kabul city, room air
was significantly more effective than commercially available
oxygen to increase oxygen saturation and as effective as
commercially available oxygen to elevate Apgar scores in the
resuscitation of asphyxiated term neonates. The difference
in the mortality was not statistically significant in both the
groups. The efficacy of room air did not appear statistically
significant for the resuscitation of preterm neonates. |
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| ISSN: | 2277-8527 2455-6890 |