Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation

Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation

The actin nucleating and polymerizing formin-like 2 (FMNL2) is upregulated in several cancers and has been shown to play important roles in cell migration, invasion, cell–cell adhesion and filopodia formation. Here, using structured illumination microscopy we show that FMNL2 promotes rapid and highl...

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Bibliographic Details
Main Authors: Lina Lorenzen, Dennis Frank, Carsten Schwan, Robert Grosse
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
actin
formins
FMNL2
filopodia
protein kinase C
Online Access:https://www.mdpi.com/2218-273X/13/3/548

Internet

https://www.mdpi.com/2218-273X/13/3/548

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