Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies
Introduction:The most important side effect of therapeutics given for cancer treatment is febrile neutropenia. Neutropenia expected to be longer than seven days and severe neutropenia (absolute neutrophil count <100/mm3) especially in hematologic cancers and solid organ tumors that show bone...
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| Format: | Article |
| Language: | English |
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Mustafa Kemal University
2019-03-01
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| Series: | Mustafa Kemal Üniversitesi Tıp Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/mkutfd/issue/44115/489213?publisher=mku |
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| author | Ersin Töret Tuba Hilkay Karapınar Muhammet Bulut Ahu Aksay Yılmaz Ay Yeşim Oymak İlker Devrim Dilek Güneş İnce |
| author_facet | Ersin Töret Tuba Hilkay Karapınar Muhammet Bulut Ahu Aksay Yılmaz Ay Yeşim Oymak İlker Devrim Dilek Güneş İnce |
| author_sort | Ersin Töret |
| collection | DOAJ |
| description | Introduction:The most important side effect of therapeutics given for cancer treatment is febrile neutropenia. Neutropenia expected to be longer than seven days and severe neutropenia (absolute neutrophil count <100/mm3) especially in hematologic cancers and solid organ tumors that show bone marrow dissemination is accepted as a high-risk feature by American Infectious Disease Society. The emergent approach to a febrile neutropenia attack is to give intravascular antibiotherapy within the shortest time possible. We aimed to evaluate the febrile neutropenia attacks of pediatric cancer patients in a tertiary referral hospital during a 27-month period.Methods:Febrile neutropenia attacks of cases treated between January 2012 and March 2014 were investigated retrospectively from the patient files. Febrile neutropenia was defined as absolute neutrophil count below 500/mm3 or between 500-1000/ mm3 but expected to fall below 500/mm3 within 48 hours in the presence of fever of 38,50C with single axillary measurement or above 380C for one hour or two measurements above 380C within 4 hours.Results:One hundred thirty-one febrile neutropenia attacks of 48 patients were investigated retrospectively. Fever was managed within 24 hours in 69% patients. Peripheral and catheter-drawn blood cultures showed bacterial growth in 36% of the attacks, 64% of these growths being gram negative bacteria. Empirical treatment with piperacilin-taxobactam was observed to be efficient in 32% of the attacks. As a supportive treatment, cases received G-CSF in 19% of the attacks.Conclusion:In order to, minimize morbidity and mortality of febrile neutropenia, wide spectrum antibiotics must be given intravenously within the shortest time possible in pediatric cancers. |
| first_indexed | 2024-04-10T14:40:44Z |
| format | Article |
| id | doaj.art-b169b6cf4c884e6aafb69514c8d350c5 |
| institution | Directory Open Access Journal |
| issn | 2149-3103 |
| language | English |
| last_indexed | 2024-04-10T14:40:44Z |
| publishDate | 2019-03-01 |
| publisher | Mustafa Kemal University |
| record_format | Article |
| series | Mustafa Kemal Üniversitesi Tıp Dergisi |
| spelling | doaj.art-b169b6cf4c884e6aafb69514c8d350c52023-02-15T16:08:14ZengMustafa Kemal UniversityMustafa Kemal Üniversitesi Tıp Dergisi2149-31032019-03-0110366910.17944/mkutfd.489213102Evaluation of Febrile Neutropenic Episodes of Childhood MalignanciesErsin TöretTuba Hilkay KarapınarMuhammet BulutAhu AksayYılmaz AyYeşim Oymakİlker DevrimDilek Güneş İnceIntroduction:The most important side effect of therapeutics given for cancer treatment is febrile neutropenia. Neutropenia expected to be longer than seven days and severe neutropenia (absolute neutrophil count <100/mm3) especially in hematologic cancers and solid organ tumors that show bone marrow dissemination is accepted as a high-risk feature by American Infectious Disease Society. The emergent approach to a febrile neutropenia attack is to give intravascular antibiotherapy within the shortest time possible. We aimed to evaluate the febrile neutropenia attacks of pediatric cancer patients in a tertiary referral hospital during a 27-month period.Methods:Febrile neutropenia attacks of cases treated between January 2012 and March 2014 were investigated retrospectively from the patient files. Febrile neutropenia was defined as absolute neutrophil count below 500/mm3 or between 500-1000/ mm3 but expected to fall below 500/mm3 within 48 hours in the presence of fever of 38,50C with single axillary measurement or above 380C for one hour or two measurements above 380C within 4 hours.Results:One hundred thirty-one febrile neutropenia attacks of 48 patients were investigated retrospectively. Fever was managed within 24 hours in 69% patients. Peripheral and catheter-drawn blood cultures showed bacterial growth in 36% of the attacks, 64% of these growths being gram negative bacteria. Empirical treatment with piperacilin-taxobactam was observed to be efficient in 32% of the attacks. As a supportive treatment, cases received G-CSF in 19% of the attacks.Conclusion:In order to, minimize morbidity and mortality of febrile neutropenia, wide spectrum antibiotics must be given intravenously within the shortest time possible in pediatric cancers.http://dergipark.gov.tr/mkutfd/issue/44115/489213?publisher=mkuÇocukluk çağıfebril nötropenikanserlösemiChildhoodfebrile neutropeniacancerleukemia |
| spellingShingle | Ersin Töret Tuba Hilkay Karapınar Muhammet Bulut Ahu Aksay Yılmaz Ay Yeşim Oymak İlker Devrim Dilek Güneş İnce Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies Mustafa Kemal Üniversitesi Tıp Dergisi Çocukluk çağı febril nötropeni kanser lösemi Childhood febrile neutropenia cancer leukemia |
| title | Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies |
| title_full | Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies |
| title_fullStr | Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies |
| title_full_unstemmed | Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies |
| title_short | Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies |
| title_sort | evaluation of febrile neutropenic episodes of childhood malignancies |
| topic | Çocukluk çağı febril nötropeni kanser lösemi Childhood febrile neutropenia cancer leukemia |
| url | http://dergipark.gov.tr/mkutfd/issue/44115/489213?publisher=mku |
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