Risk of sequelae after invasive meningococcal disease
Abstract Background Invasive meningococcal disease (IMD) is a rare but severe bacterial infection, of which a high proportion of survivors are affected by sequelae. In Denmark, IMD is a notifiable disease and data collection on sequelae information has been automated, enabling studies of sequelae du...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07129-4 |
| _version_ | 1818330379267866624 |
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| author | Sidsel Skou Voss Jens Nielsen Palle Valentiner-Branth |
| author_facet | Sidsel Skou Voss Jens Nielsen Palle Valentiner-Branth |
| author_sort | Sidsel Skou Voss |
| collection | DOAJ |
| description | Abstract Background Invasive meningococcal disease (IMD) is a rare but severe bacterial infection, of which a high proportion of survivors are affected by sequelae. In Denmark, IMD is a notifiable disease and data collection on sequelae information has been automated, enabling studies of sequelae due to IMD diagnosed after discharge. The aim of this study was to examine possible determinants for sequelae after IMD and to describe the distribution of sequelae by age, serogroup and clinical presentation, for all cases in Denmark from 2005–2020. Methods Data from The National Database for Notifiable Infectious Diseases was linked to data from The Danish National Patient Register and the Civil Registration System. Logistic regression models were used to study whether age, serogroup and/or clinical presentation were associated with sequelae. A descriptive analysis of the proportion of different types of sequelae across age groups, serogroups and clinical presentations was performed. Results In total, 25% of IMD survivors experienced one or more sequelae. We found no significant association between sequelae and age. The five most common sequelae in decreasing order of incidence were hearing loss, epilepsy, learning disabilities, headache and visual defects/loss of vision, with rates ranging from 8.2 to 2.8% of IMD survivors. The proportion of survivors with hearing loss and visual defects/loss of vision was not significantly different between clinical presentations. Conclusions We suggest revising IMD treatment guidelines, to include routine referral to hearing and vision tests, irrespective of clinical presentation. Furthermore, it is important to increase the awareness among parents of children who have had IMD of possible future learning disabilities to make sure that necessary measures are taken in a timely manner. |
| first_indexed | 2024-12-13T13:03:01Z |
| format | Article |
| id | doaj.art-b16a5324b01b4472a76f25d7ef218898 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T13:03:01Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b16a5324b01b4472a76f25d7ef2188982022-12-21T23:44:55ZengBMCBMC Infectious Diseases1471-23342022-02-012211910.1186/s12879-022-07129-4Risk of sequelae after invasive meningococcal diseaseSidsel Skou Voss0Jens Nielsen1Palle Valentiner-Branth2European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC)Infectious Disease Epidemiology and Prevention, Statens Serum InstitutInfectious Disease Epidemiology and Prevention, Statens Serum InstitutAbstract Background Invasive meningococcal disease (IMD) is a rare but severe bacterial infection, of which a high proportion of survivors are affected by sequelae. In Denmark, IMD is a notifiable disease and data collection on sequelae information has been automated, enabling studies of sequelae due to IMD diagnosed after discharge. The aim of this study was to examine possible determinants for sequelae after IMD and to describe the distribution of sequelae by age, serogroup and clinical presentation, for all cases in Denmark from 2005–2020. Methods Data from The National Database for Notifiable Infectious Diseases was linked to data from The Danish National Patient Register and the Civil Registration System. Logistic regression models were used to study whether age, serogroup and/or clinical presentation were associated with sequelae. A descriptive analysis of the proportion of different types of sequelae across age groups, serogroups and clinical presentations was performed. Results In total, 25% of IMD survivors experienced one or more sequelae. We found no significant association between sequelae and age. The five most common sequelae in decreasing order of incidence were hearing loss, epilepsy, learning disabilities, headache and visual defects/loss of vision, with rates ranging from 8.2 to 2.8% of IMD survivors. The proportion of survivors with hearing loss and visual defects/loss of vision was not significantly different between clinical presentations. Conclusions We suggest revising IMD treatment guidelines, to include routine referral to hearing and vision tests, irrespective of clinical presentation. Furthermore, it is important to increase the awareness among parents of children who have had IMD of possible future learning disabilities to make sure that necessary measures are taken in a timely manner.https://doi.org/10.1186/s12879-022-07129-4SequelaeInvasive meningococcal diseaseEpidemiologyDeterminants/factorsSurveillance |
| spellingShingle | Sidsel Skou Voss Jens Nielsen Palle Valentiner-Branth Risk of sequelae after invasive meningococcal disease BMC Infectious Diseases Sequelae Invasive meningococcal disease Epidemiology Determinants/factors Surveillance |
| title | Risk of sequelae after invasive meningococcal disease |
| title_full | Risk of sequelae after invasive meningococcal disease |
| title_fullStr | Risk of sequelae after invasive meningococcal disease |
| title_full_unstemmed | Risk of sequelae after invasive meningococcal disease |
| title_short | Risk of sequelae after invasive meningococcal disease |
| title_sort | risk of sequelae after invasive meningococcal disease |
| topic | Sequelae Invasive meningococcal disease Epidemiology Determinants/factors Surveillance |
| url | https://doi.org/10.1186/s12879-022-07129-4 |
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