The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering
Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing duration or even failure. The current gold standard therapy in...
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/975 |
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| author | Wolfgang Mende Rebekka Götzl Yusuke Kubo Thomas Pufe Tim Ruhl Justus P. Beier |
| author_facet | Wolfgang Mende Rebekka Götzl Yusuke Kubo Thomas Pufe Tim Ruhl Justus P. Beier |
| author_sort | Wolfgang Mende |
| collection | DOAJ |
| description | Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing duration or even failure. The current gold standard therapy in these cases are bone grafts. However, they are associated with several disadvantages, e.g., donor site morbidity and availability of appropriate material. Bone tissue engineering has been proposed as a promising alternative. The success of bone-tissue engineering depends on the administered cells, osteogenic differentiation, and secretome. Different stem cell types offer advantages and drawbacks in this field, while adipose-derived stem or stromal cells (ASCs) are in particular promising. They show high osteogenic potential, osteoinductive ability, and immunomodulation properties. Furthermore, they can be harvested through a noninvasive process in high numbers. ASCs can be induced into osteogenic lineage through bioactive molecules, i.e., growth factors and cytokines. Moreover, their secretome, in particular extracellular vesicles, has been linked to fracture healing. The aim of this review is a comprehensive overview of ASCs for bone regeneration and bone tissue engineering. |
| first_indexed | 2024-03-10T12:06:57Z |
| format | Article |
| id | doaj.art-b16c44d0a9d0463c80deae26e08686e6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T12:06:57Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b16c44d0a9d0463c80deae26e08686e62023-11-21T16:33:13ZengMDPI AGCells2073-44092021-04-0110597510.3390/cells10050975The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue EngineeringWolfgang Mende0Rebekka Götzl1Yusuke Kubo2Thomas Pufe3Tim Ruhl4Justus P. Beier5Hand Surgery—Burn Center, Department of Plastic Surgery, RWTH Aachen University Hospital, 52074 Aachen, GermanyHand Surgery—Burn Center, Department of Plastic Surgery, RWTH Aachen University Hospital, 52074 Aachen, GermanyDepartment of Anatomy and Cell Biology, RWTH Aachen University Hospital, 52074 Aachen, GermanyDepartment of Anatomy and Cell Biology, RWTH Aachen University Hospital, 52074 Aachen, GermanyHand Surgery—Burn Center, Department of Plastic Surgery, RWTH Aachen University Hospital, 52074 Aachen, GermanyHand Surgery—Burn Center, Department of Plastic Surgery, RWTH Aachen University Hospital, 52074 Aachen, GermanyBone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing duration or even failure. The current gold standard therapy in these cases are bone grafts. However, they are associated with several disadvantages, e.g., donor site morbidity and availability of appropriate material. Bone tissue engineering has been proposed as a promising alternative. The success of bone-tissue engineering depends on the administered cells, osteogenic differentiation, and secretome. Different stem cell types offer advantages and drawbacks in this field, while adipose-derived stem or stromal cells (ASCs) are in particular promising. They show high osteogenic potential, osteoinductive ability, and immunomodulation properties. Furthermore, they can be harvested through a noninvasive process in high numbers. ASCs can be induced into osteogenic lineage through bioactive molecules, i.e., growth factors and cytokines. Moreover, their secretome, in particular extracellular vesicles, has been linked to fracture healing. The aim of this review is a comprehensive overview of ASCs for bone regeneration and bone tissue engineering.https://www.mdpi.com/2073-4409/10/5/975mesenchymal stem cellsregenerative medicinefracture healingosteogenic differentiationosteogenesismechanic stimuli |
| spellingShingle | Wolfgang Mende Rebekka Götzl Yusuke Kubo Thomas Pufe Tim Ruhl Justus P. Beier The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering Cells mesenchymal stem cells regenerative medicine fracture healing osteogenic differentiation osteogenesis mechanic stimuli |
| title | The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering |
| title_full | The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering |
| title_fullStr | The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering |
| title_full_unstemmed | The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering |
| title_short | The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering |
| title_sort | role of adipose stem cells in bone regeneration and bone tissue engineering |
| topic | mesenchymal stem cells regenerative medicine fracture healing osteogenic differentiation osteogenesis mechanic stimuli |
| url | https://www.mdpi.com/2073-4409/10/5/975 |
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