Heterogeneous catalytic direct amide bond formation
The synthesis of amides by the direct reaction of carboxylic acids with amines is an industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental process for the construction of proteins in living organisms. To promote this process, the use of heterogeneous catalysts...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-04-01
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| Series: | Catalysis Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1566736722000255 |
| _version_ | 1819121518839332864 |
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| author | Nuria Martín Francisco G. Cirujano |
| author_facet | Nuria Martín Francisco G. Cirujano |
| author_sort | Nuria Martín |
| collection | DOAJ |
| description | The synthesis of amides by the direct reaction of carboxylic acids with amines is an industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental process for the construction of proteins in living organisms. To promote this process, the use of heterogeneous catalysts is preferred over their homogeneous counterparts, due to their advantages related to simple isolation, recovery and recycling. In addition, peptide bond formation over solid surfaces is interesting not only from the point of view of industrial organic synthesis but also from their implications in the understanding of prebiotic chemistry. For all this, we have highlighted some of the most relevant reported heterogeneous catalysts for the direct amide bond formation, focusing not only on the physicochemical properties of the solid catalyst –such as porosity and acidity- and its catalytic performance but also on the current understanding of the reaction mechanism. Different types of active sites incorporated at the surface (and bulk) of the solid are reviewed here: inorganic, organic and hybrid organic-inorganic. Besides the nature of the active sites, their interplay with the support in which they are embedded is thoroughly described, where surface area and pore size are key properties of the solid catalyst. |
| first_indexed | 2024-12-22T06:37:50Z |
| format | Article |
| id | doaj.art-b16c6f4f34a14b71881eb37cc42f6c00 |
| institution | Directory Open Access Journal |
| issn | 1873-3905 |
| language | English |
| last_indexed | 2024-12-22T06:37:50Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Catalysis Communications |
| spelling | doaj.art-b16c6f4f34a14b71881eb37cc42f6c002022-12-21T18:35:32ZengElsevierCatalysis Communications1873-39052022-04-01164106420Heterogeneous catalytic direct amide bond formationNuria Martín0Francisco G. Cirujano1Corresponding authors.; Institute of Molecular Science (ICMOL), Universidad de Valencia, 46980 Paterna, Valencia, SpainCorresponding authors.; Institute of Molecular Science (ICMOL), Universidad de Valencia, 46980 Paterna, Valencia, SpainThe synthesis of amides by the direct reaction of carboxylic acids with amines is an industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental process for the construction of proteins in living organisms. To promote this process, the use of heterogeneous catalysts is preferred over their homogeneous counterparts, due to their advantages related to simple isolation, recovery and recycling. In addition, peptide bond formation over solid surfaces is interesting not only from the point of view of industrial organic synthesis but also from their implications in the understanding of prebiotic chemistry. For all this, we have highlighted some of the most relevant reported heterogeneous catalysts for the direct amide bond formation, focusing not only on the physicochemical properties of the solid catalyst –such as porosity and acidity- and its catalytic performance but also on the current understanding of the reaction mechanism. Different types of active sites incorporated at the surface (and bulk) of the solid are reviewed here: inorganic, organic and hybrid organic-inorganic. Besides the nature of the active sites, their interplay with the support in which they are embedded is thoroughly described, where surface area and pore size are key properties of the solid catalyst.http://www.sciencedirect.com/science/article/pii/S1566736722000255Heterogeneous catalysisAmide formationMetal oxideZeoliteOrdered porous silicaMetal-organic framework |
| spellingShingle | Nuria Martín Francisco G. Cirujano Heterogeneous catalytic direct amide bond formation Catalysis Communications Heterogeneous catalysis Amide formation Metal oxide Zeolite Ordered porous silica Metal-organic framework |
| title | Heterogeneous catalytic direct amide bond formation |
| title_full | Heterogeneous catalytic direct amide bond formation |
| title_fullStr | Heterogeneous catalytic direct amide bond formation |
| title_full_unstemmed | Heterogeneous catalytic direct amide bond formation |
| title_short | Heterogeneous catalytic direct amide bond formation |
| title_sort | heterogeneous catalytic direct amide bond formation |
| topic | Heterogeneous catalysis Amide formation Metal oxide Zeolite Ordered porous silica Metal-organic framework |
| url | http://www.sciencedirect.com/science/article/pii/S1566736722000255 |
| work_keys_str_mv | AT nuriamartin heterogeneouscatalyticdirectamidebondformation AT franciscogcirujano heterogeneouscatalyticdirectamidebondformation |