Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
Background Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points d...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2018-04-01
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| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | http://www.ijfs.ir/article_45461_899bf6902d39d76674fd2ade98f50192.pdf |
| _version_ | 1819229574394806272 |
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| author | Azadeh Ghaheri Aliakbar Rasekhi Reza Omani Samani Ebrahim Hajizadeh |
| author_facet | Azadeh Ghaheri Aliakbar Rasekhi Reza Omani Samani Ebrahim Hajizadeh |
| author_sort | Azadeh Ghaheri |
| collection | DOAJ |
| description | Background Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. Materials and Methods This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women. Covariates considered in this study were women’s age, type of cycle (fresh or frozen embryo transfer), number of embryos transferred and having polycystic ovarian syndrome during IVF cycles. Generalized estimating equations were used for calculation of odds ratio (OR) and 95% confidence intervals (95% CI) of success at different stages during IVF cycles. Cluster-weighted generalized estimating equations (CWGEE) was also fitted to handle informative cluster size. Results After adjusting for potential confounders, it was seen that receiving frozen embryo transfer was associated with higher odds of success compared to receiving fresh embryo transfer (adj OR: 2.26, 95% CI: 1.66-3.07); however, cycles with fresh embryo transfer exhibited better results in clinical pregnancy compared to those receiving frozen embryo. Being in the age category of 38 to 40 was associated with lower odds of success compared to the reference category ( |
| first_indexed | 2024-12-23T11:15:20Z |
| format | Article |
| id | doaj.art-b16de777ae654531a63fe9ccb745918c |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-23T11:15:20Z |
| publishDate | 2018-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-b16de777ae654531a63fe9ccb745918c2022-12-21T17:49:13ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782018-04-01121273010.22074/ijfs.2018.518745461Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile WomenAzadeh Ghaheri0Aliakbar Rasekhi1Reza Omani Samani2Ebrahim Hajizadeh3Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranBackground Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. Materials and Methods This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women. Covariates considered in this study were women’s age, type of cycle (fresh or frozen embryo transfer), number of embryos transferred and having polycystic ovarian syndrome during IVF cycles. Generalized estimating equations were used for calculation of odds ratio (OR) and 95% confidence intervals (95% CI) of success at different stages during IVF cycles. Cluster-weighted generalized estimating equations (CWGEE) was also fitted to handle informative cluster size. Results After adjusting for potential confounders, it was seen that receiving frozen embryo transfer was associated with higher odds of success compared to receiving fresh embryo transfer (adj OR: 2.26, 95% CI: 1.66-3.07); however, cycles with fresh embryo transfer exhibited better results in clinical pregnancy compared to those receiving frozen embryo. Being in the age category of 38 to 40 was associated with lower odds of success compared to the reference category (http://www.ijfs.ir/article_45461_899bf6902d39d76674fd2ade98f50192.pdfcluster analysisinfertilityfertilization |
| spellingShingle | Azadeh Ghaheri Aliakbar Rasekhi Reza Omani Samani Ebrahim Hajizadeh Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women International Journal of Fertility and Sterility cluster analysis infertility fertilization |
| title | Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women |
| title_full | Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women |
| title_fullStr | Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women |
| title_full_unstemmed | Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women |
| title_short | Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women |
| title_sort | modeling in vitro fertilization data considering multiple outcomes observed among iranian infertile women |
| topic | cluster analysis infertility fertilization |
| url | http://www.ijfs.ir/article_45461_899bf6902d39d76674fd2ade98f50192.pdf |
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