Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications
Successful outcomes of in vitro fertilization (IVF) rely on both the formation of a chromosomally normal embryo and its implantation in a receptive endometrium. Pre-implantation genetic testing for aneuploidy (PGT-A) has been widely accepted as a tool to assess the viability of an embryo. In 2011, t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/749 |
| _version_ | 1797599540121960448 |
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| author | Sarah C. Rubin Mawerdi Abdulkadir Joshua Lewis Aleksandr Harutyunyan Rahim Hirani Cara L. Grimes |
| author_facet | Sarah C. Rubin Mawerdi Abdulkadir Joshua Lewis Aleksandr Harutyunyan Rahim Hirani Cara L. Grimes |
| author_sort | Sarah C. Rubin |
| collection | DOAJ |
| description | Successful outcomes of in vitro fertilization (IVF) rely on both the formation of a chromosomally normal embryo and its implantation in a receptive endometrium. Pre-implantation genetic testing for aneuploidy (PGT-A) has been widely accepted as a tool to assess the viability of an embryo. In 2011, the endometrial receptivity array (ERA) was first published as a tool to determine when the endometrium is most receptive to an embryo, commonly referred to as the “window of implantation” (WOI). The ERA uses molecular arrays to assess proliferation and differentiation in the endometrium and screens for inflammatory markers. Unlike PGT-A, there has been dissent within the field concerning the efficacy of the ERA. Many studies that contest the success of the ERA found that it did not improve pregnancy outcomes in patients with an already-good prognosis. Alternatively, studies that utilized the ERA in patients with repeated implantation failure (RIF) and transfer of known euploid embryos demonstrated improved outcomes. This review aims to describe the ERA as a novel technique, review the various settings that the ERA may be used in, such as natural frozen embryo transfer (nFET) and hormone replacement therapy frozen embryo transfer (HRT-FET), and provide a summary of the recent clinical data for embryo transfers in patients with RIF utilizing the ERA. |
| first_indexed | 2024-03-11T03:35:46Z |
| format | Article |
| id | doaj.art-b16dfb89d4c7494e875b72e7a2fdbb9d |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:46Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-b16dfb89d4c7494e875b72e7a2fdbb9d2023-11-18T02:03:35ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113574910.3390/jpm13050749Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical ApplicationsSarah C. Rubin0Mawerdi Abdulkadir1Joshua Lewis2Aleksandr Harutyunyan3Rahim Hirani4Cara L. Grimes5School of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USASuccessful outcomes of in vitro fertilization (IVF) rely on both the formation of a chromosomally normal embryo and its implantation in a receptive endometrium. Pre-implantation genetic testing for aneuploidy (PGT-A) has been widely accepted as a tool to assess the viability of an embryo. In 2011, the endometrial receptivity array (ERA) was first published as a tool to determine when the endometrium is most receptive to an embryo, commonly referred to as the “window of implantation” (WOI). The ERA uses molecular arrays to assess proliferation and differentiation in the endometrium and screens for inflammatory markers. Unlike PGT-A, there has been dissent within the field concerning the efficacy of the ERA. Many studies that contest the success of the ERA found that it did not improve pregnancy outcomes in patients with an already-good prognosis. Alternatively, studies that utilized the ERA in patients with repeated implantation failure (RIF) and transfer of known euploid embryos demonstrated improved outcomes. This review aims to describe the ERA as a novel technique, review the various settings that the ERA may be used in, such as natural frozen embryo transfer (nFET) and hormone replacement therapy frozen embryo transfer (HRT-FET), and provide a summary of the recent clinical data for embryo transfers in patients with RIF utilizing the ERA.https://www.mdpi.com/2075-4426/13/5/749endometrial receptivity arrayin vitro fertilizationpre-implantation testingfrozen embryo transferhormone replacement therapyimplantation failure |
| spellingShingle | Sarah C. Rubin Mawerdi Abdulkadir Joshua Lewis Aleksandr Harutyunyan Rahim Hirani Cara L. Grimes Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications Journal of Personalized Medicine endometrial receptivity array in vitro fertilization pre-implantation testing frozen embryo transfer hormone replacement therapy implantation failure |
| title | Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications |
| title_full | Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications |
| title_fullStr | Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications |
| title_full_unstemmed | Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications |
| title_short | Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications |
| title_sort | review of endometrial receptivity array a personalized approach to embryo transfer and its clinical applications |
| topic | endometrial receptivity array in vitro fertilization pre-implantation testing frozen embryo transfer hormone replacement therapy implantation failure |
| url | https://www.mdpi.com/2075-4426/13/5/749 |
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