Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study.
Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have been used to indicate endotheliopathy, and are associated with inflammation, coagulopathy, and mortality. The current study aimed to...
Main Authors: | David N Naumann, Jon Hazeldine, Robert J Dinsdale, Jon R Bishop, Mark J Midwinter, Paul Harrison, Sam D Hutchings, Janet M Lord |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5736230?pdf=render |
Similar Items
-
Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation
by: Jon Hazeldine, et al.
Published: (2019-04-01) -
The impact of trauma relevant concentrations of prostaglandin E2 on the anti-microbial activity of the innate immune system
by: Thomas Nicholson, et al.
Published: (2024-10-01) -
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
by: Jon Hazeldine, et al.
Published: (2020-10-01) -
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
by: Jon Hazeldine, et al.
Published: (2021-06-01) -
The immune suppressive properties of damage associated molecular patterns in the setting of sterile traumatic injury
by: Emily Horner, et al.
Published: (2023-08-01)