Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas
Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. He...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/16/8881 |
| _version_ | 1797523586120941568 |
|---|---|
| author | Cheng-Ming Hsu Ming-Yu Yang Ming-Shao Tsai Geng-He Chang Yao-Hsu Yang Yao-Te Tsai Ching-Yuan Wu Shun-Fu Chang |
| author_facet | Cheng-Ming Hsu Ming-Yu Yang Ming-Shao Tsai Geng-He Chang Yao-Hsu Yang Yao-Te Tsai Ching-Yuan Wu Shun-Fu Chang |
| author_sort | Cheng-Ming Hsu |
| collection | DOAJ |
| description | Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (<i>Salvia miltiorrhiza</i>), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy. |
| first_indexed | 2024-03-10T08:44:10Z |
| format | Article |
| id | doaj.art-b173fc12b5414dbaa01c089dd7e6a641 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:44:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b173fc12b5414dbaa01c089dd7e6a6412023-11-22T08:01:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216888110.3390/ijms22168881Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell CarcinomasCheng-Ming Hsu0Ming-Yu Yang1Ming-Shao Tsai2Geng-He Chang3Yao-Hsu Yang4Yao-Te Tsai5Ching-Yuan Wu6Shun-Fu Chang7Department of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, TaiwanHead and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (<i>Salvia miltiorrhiza</i>), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy.https://www.mdpi.com/1422-0067/22/16/8881head and neck squamous cell carcinomadanshen<i>Salvia miltiorrhiza</i>dihydroisotanshinone Iapoptosisp38 signaling |
| spellingShingle | Cheng-Ming Hsu Ming-Yu Yang Ming-Shao Tsai Geng-He Chang Yao-Hsu Yang Yao-Te Tsai Ching-Yuan Wu Shun-Fu Chang Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas International Journal of Molecular Sciences head and neck squamous cell carcinoma danshen <i>Salvia miltiorrhiza</i> dihydroisotanshinone I apoptosis p38 signaling |
| title | Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas |
| title_full | Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas |
| title_fullStr | Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas |
| title_full_unstemmed | Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas |
| title_short | Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas |
| title_sort | dihydroisotanshinone i as a treatment option for head and neck squamous cell carcinomas |
| topic | head and neck squamous cell carcinoma danshen <i>Salvia miltiorrhiza</i> dihydroisotanshinone I apoptosis p38 signaling |
| url | https://www.mdpi.com/1422-0067/22/16/8881 |
| work_keys_str_mv | AT chengminghsu dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT mingyuyang dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT mingshaotsai dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT genghechang dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT yaohsuyang dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT yaotetsai dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT chingyuanwu dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas AT shunfuchang dihydroisotanshinoneiasatreatmentoptionforheadandnecksquamouscellcarcinomas |