Factors associated with real-world functioning in first stages of schizophrenia disorder
Introduction Schizophrenia is one of the most disabling diseases affecting the patient’s ability to live independently, to be socially active and to work or study1,2. Therefore, identifying predictors of functioning in the first stages of the disease is important to prevent a negative progression...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821021283/type/journal_article |
| _version_ | 1797616952428986368 |
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| author | C. Martínez-Cao A. García-Fernández M. Valtueña-García M.P. García-Portilla J. Bobes |
| author_facet | C. Martínez-Cao A. García-Fernández M. Valtueña-García M.P. García-Portilla J. Bobes |
| author_sort | C. Martínez-Cao |
| collection | DOAJ |
| description |
Introduction
Schizophrenia is one of the most disabling diseases affecting the patient’s ability to live independently, to be socially active and to work or study1,2. Therefore, identifying predictors of functioning in the first stages of the disease is important to prevent a negative progression of functional outcome in these patients3.
Objectives
To identify the factors associated with real-world functioning in patients with recent onset of the disease.
Methods
Secondary analysis of a cross-sectional, naturalistic study. 84 patients with Schizophrenia (F20), aged 18-71 in their first five years of the disorder under maintenance treatment. Assessments: PANSS, CDS, CGI-S, CAINS; functioning: PSP, cognition: MATRICS. Statistical analysis: student-t test, ANOVA, Pearson correlation and lineal regression.
Results
Mean age (SD): 31.30 (10.08); men: 62.8%. Statistical significant differences (p<0.05) were found in work status, benzodiazepines and antidepressants use. Furthermore, significant correlations (p<0.05) were found with depressive, positive and negative symptoms (avolition, anhedonia, alogia and affective flattening) and cognition. A significant predictive model was obtained that explains the 72.1% of the variance [F(5,74)= 20.952; p< 0.001]. This model included depressive symptoms (B= -0.940; p= 0.001), negative symptoms (B= -1.696; p< 0.001), avolition and anhedonia (B= -0.643; p= 0.001), affective flattening and alogia (B= 1.197; p= 0.003), and visual learning (B= 0.202 p= 0.039).
Conclusions
Negative and depressive symptoms are the main determinants of real-world functioning in patients with recent onset of schizophrenia. Visual learning also contributes to this outcome. On the other hand, the positive relationship between expressive domain and functioning needs furthermore investigation.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:48:31Z |
| format | Article |
| id | doaj.art-b1767584a1824525ba515735fd7948ab |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:48:31Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-b1767584a1824525ba515735fd7948ab2023-11-17T05:07:16ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S805S80510.1192/j.eurpsy.2021.2128Factors associated with real-world functioning in first stages of schizophrenia disorderC. Martínez-Cao0A. García-Fernández1M. Valtueña-García2 M.P. García-Portilla3J. Bobes4Department Of Psychiatry, University of Oviedo, Oviedo, SpainDepartment Of Psychiatry, University of Oviedo, Oviedo, SpainDepartment Of Psychiatry, University of Oviedo, Oviedo, SpainDepartment Of Psychiatry, University of Oviedo, Oviedo, SpainDepartment Of Psychiatry, University of Oviedo, Oviedo, Spain Introduction Schizophrenia is one of the most disabling diseases affecting the patient’s ability to live independently, to be socially active and to work or study1,2. Therefore, identifying predictors of functioning in the first stages of the disease is important to prevent a negative progression of functional outcome in these patients3. Objectives To identify the factors associated with real-world functioning in patients with recent onset of the disease. Methods Secondary analysis of a cross-sectional, naturalistic study. 84 patients with Schizophrenia (F20), aged 18-71 in their first five years of the disorder under maintenance treatment. Assessments: PANSS, CDS, CGI-S, CAINS; functioning: PSP, cognition: MATRICS. Statistical analysis: student-t test, ANOVA, Pearson correlation and lineal regression. Results Mean age (SD): 31.30 (10.08); men: 62.8%. Statistical significant differences (p<0.05) were found in work status, benzodiazepines and antidepressants use. Furthermore, significant correlations (p<0.05) were found with depressive, positive and negative symptoms (avolition, anhedonia, alogia and affective flattening) and cognition. A significant predictive model was obtained that explains the 72.1% of the variance [F(5,74)= 20.952; p< 0.001]. This model included depressive symptoms (B= -0.940; p= 0.001), negative symptoms (B= -1.696; p< 0.001), avolition and anhedonia (B= -0.643; p= 0.001), affective flattening and alogia (B= 1.197; p= 0.003), and visual learning (B= 0.202 p= 0.039). Conclusions Negative and depressive symptoms are the main determinants of real-world functioning in patients with recent onset of schizophrenia. Visual learning also contributes to this outcome. On the other hand, the positive relationship between expressive domain and functioning needs furthermore investigation. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821021283/type/journal_articlepsychosisFunctioningschizophréniarecent onset |
| spellingShingle | C. Martínez-Cao A. García-Fernández M. Valtueña-García M.P. García-Portilla J. Bobes Factors associated with real-world functioning in first stages of schizophrenia disorder European Psychiatry psychosis Functioning schizophrénia recent onset |
| title | Factors associated with real-world functioning in first stages of schizophrenia disorder |
| title_full | Factors associated with real-world functioning in first stages of schizophrenia disorder |
| title_fullStr | Factors associated with real-world functioning in first stages of schizophrenia disorder |
| title_full_unstemmed | Factors associated with real-world functioning in first stages of schizophrenia disorder |
| title_short | Factors associated with real-world functioning in first stages of schizophrenia disorder |
| title_sort | factors associated with real world functioning in first stages of schizophrenia disorder |
| topic | psychosis Functioning schizophrénia recent onset |
| url | https://www.cambridge.org/core/product/identifier/S0924933821021283/type/journal_article |
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