Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion
Due to its non-invasive and highly effective characteristics, radiotherapy has attracted significant interest in cancer treatment. However, radioresistance of solid tumors caused by a unique tumor microenvironment diminishes the therapeutic effect of cancer radiotherapy. To address this issue, we de...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1054608/full |
| _version_ | 1798015725028245504 |
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| author | Xiaoxiang Zhou Xiang Li Bo Wu Zhiran Chen Longyun Chen |
| author_facet | Xiaoxiang Zhou Xiang Li Bo Wu Zhiran Chen Longyun Chen |
| author_sort | Xiaoxiang Zhou |
| collection | DOAJ |
| description | Due to its non-invasive and highly effective characteristics, radiotherapy has attracted significant interest in cancer treatment. However, radioresistance of solid tumors caused by a unique tumor microenvironment diminishes the therapeutic effect of cancer radiotherapy. To address this issue, we developed a nanoplatform for tumor-specific targeting to improve radiotherapy. Specifically, hollow CuS nanoparticles were decorated with the platelet cell membrane (PC), endowing this nanoplatform with the therapeutic property of navigating to the tumor region for glutathione (GSH)-depletion photothermal therapy. It was discovered that mild photothermal therapy mediated by PC ameliorated hypoxia in the tumor microenvironment. Meanwhile, GSH, which contributes to repairing radiotherapy-induced DNA double-strand breaks, was depleted by PC in an acidic microenvironment. Therefore, radioresistance could be diminished while cancer cell self-repair was prevented. At therapeutic doses, PC nanoparticles have negligible toxic effects on normal tissues. PC demonstrates promise for both in vivo and in vitro radiosensitization due to its GSH-depletion, photothermal efficiency, and tumor-specific properties. |
| first_indexed | 2024-04-11T15:38:27Z |
| format | Article |
| id | doaj.art-b176c4b39692450585b72e4f910b68c2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T15:38:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b176c4b39692450585b72e4f910b68c22022-12-22T04:15:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10546081054608Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletionXiaoxiang Zhou0Xiang Li1Bo Wu2Zhiran Chen3Longyun Chen4The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People’s Hospital, Yanchen, ChinaDepartment of Central Laboratory and Precision Medicine Center, Department of Nephrology, The Affiliated Huai’an Hospital of Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, ChinaThe Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People’s Hospital, Yanchen, ChinaThe Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People’s Hospital, Yanchen, ChinaThe Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People’s Hospital, Yanchen, ChinaDue to its non-invasive and highly effective characteristics, radiotherapy has attracted significant interest in cancer treatment. However, radioresistance of solid tumors caused by a unique tumor microenvironment diminishes the therapeutic effect of cancer radiotherapy. To address this issue, we developed a nanoplatform for tumor-specific targeting to improve radiotherapy. Specifically, hollow CuS nanoparticles were decorated with the platelet cell membrane (PC), endowing this nanoplatform with the therapeutic property of navigating to the tumor region for glutathione (GSH)-depletion photothermal therapy. It was discovered that mild photothermal therapy mediated by PC ameliorated hypoxia in the tumor microenvironment. Meanwhile, GSH, which contributes to repairing radiotherapy-induced DNA double-strand breaks, was depleted by PC in an acidic microenvironment. Therefore, radioresistance could be diminished while cancer cell self-repair was prevented. At therapeutic doses, PC nanoparticles have negligible toxic effects on normal tissues. PC demonstrates promise for both in vivo and in vitro radiosensitization due to its GSH-depletion, photothermal efficiency, and tumor-specific properties.https://www.frontiersin.org/articles/10.3389/fonc.2022.1054608/fullradiotherapyGSH-depletionphotothermal therapybiomimetichypoxia |
| spellingShingle | Xiaoxiang Zhou Xiang Li Bo Wu Zhiran Chen Longyun Chen Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion Frontiers in Oncology radiotherapy GSH-depletion photothermal therapy biomimetic hypoxia |
| title | Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion |
| title_full | Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion |
| title_fullStr | Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion |
| title_full_unstemmed | Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion |
| title_short | Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion |
| title_sort | biomimetic cus nanoparticles for radiosensitization with mild photothermal therapy and gsh depletion |
| topic | radiotherapy GSH-depletion photothermal therapy biomimetic hypoxia |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1054608/full |
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