The association between periodontitis and cardiovascular risks in asymptomatic healthy patients
Background: Periodontitis is a chronic multifactorial inflammatory disease of the supportive tissues of the teeth. Pathophysiological evidence suggests a possible common inflammatory background between periodontitis and cardiovascular diseases (CVD). Pathological and epidemiological associations bet...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277248752100012X |
| _version_ | 1818975581595762688 |
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| author | H.C.M. Donders E.O. Veth A.W.J. van ‘t Hof J. de Lange B.G. Loos |
| author_facet | H.C.M. Donders E.O. Veth A.W.J. van ‘t Hof J. de Lange B.G. Loos |
| author_sort | H.C.M. Donders |
| collection | DOAJ |
| description | Background: Periodontitis is a chronic multifactorial inflammatory disease of the supportive tissues of the teeth. Pathophysiological evidence suggests a possible common inflammatory background between periodontitis and cardiovascular diseases (CVD). Pathological and epidemiological associations between these two diseases have been presented, but are still debated. This study aimed to investigate the association between the inflammatory burden of periodontitis and the presence and extent of coronary calcification. Secondary aims were to study other cardiovascular parameters and cardiovascular risk predictors in relation to periodontitis and dental health. Methods: Healthy periodontitis or non-periodontitis patients 45–70 years of age were included in a prospective cross-sectional study. Full-mouth examinations were performed by a periodontist to determine their Periodontal Inflamed Surface Area (PISA) score and other dental parameters. To assess the cardiovascular conditions, Coronary Artery Calcium (CAC) scores, endothelial function assessments by the EndoPAT ™, and several physical and biochemical examinations were performed. Results: Seventy-one patients were included. Elevated CAC scores and endothelial dysfunction were not significantly related to PISA or dental health. PISA was significantly related to the Framingham and Reynolds CVD risk predictors, but were no longer significant after correction for confounders. The same applied to the significant relations between tooth loss, dental plaque and bleeding scores and the CVD risk predictors. Conclusions: Periodontitis is associated with increased CVD risk, but is not an independent risk factor. This link is still important to make to bridge the gap between dentistry and general medicine and to identify patients at risk for CVD in an earlier stage. |
| first_indexed | 2024-12-20T15:58:14Z |
| format | Article |
| id | doaj.art-b176d5cd5c7e42598bf19764eaf19487 |
| institution | Directory Open Access Journal |
| issn | 2772-4875 |
| language | English |
| last_indexed | 2024-12-20T15:58:14Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj.art-b176d5cd5c7e42598bf19764eaf194872022-12-21T19:34:22ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752021-12-0111200110The association between periodontitis and cardiovascular risks in asymptomatic healthy patientsH.C.M. Donders0E.O. Veth1A.W.J. van ‘t Hof2J. de Lange3B.G. Loos4Department of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Isala Hospital Zwolle, the Netherlands; Corresponding author. Department of Oral and Maxillofacial Surgery, Isala, Dokter van Heesweg 2, 8025 AB, Zwolle, the Netherlands.Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, the Netherlands; Practice for Periodontology Zwolle (PPZ), Zwolle, the NetherlandsDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht (CARIM), the Netherlands; Department of Cardiology, Zuyderland MC, Heerlen, the NetherlandsDepartment of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Isala Hospital Zwolle, the NetherlandsDepartment of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, the NetherlandsBackground: Periodontitis is a chronic multifactorial inflammatory disease of the supportive tissues of the teeth. Pathophysiological evidence suggests a possible common inflammatory background between periodontitis and cardiovascular diseases (CVD). Pathological and epidemiological associations between these two diseases have been presented, but are still debated. This study aimed to investigate the association between the inflammatory burden of periodontitis and the presence and extent of coronary calcification. Secondary aims were to study other cardiovascular parameters and cardiovascular risk predictors in relation to periodontitis and dental health. Methods: Healthy periodontitis or non-periodontitis patients 45–70 years of age were included in a prospective cross-sectional study. Full-mouth examinations were performed by a periodontist to determine their Periodontal Inflamed Surface Area (PISA) score and other dental parameters. To assess the cardiovascular conditions, Coronary Artery Calcium (CAC) scores, endothelial function assessments by the EndoPAT ™, and several physical and biochemical examinations were performed. Results: Seventy-one patients were included. Elevated CAC scores and endothelial dysfunction were not significantly related to PISA or dental health. PISA was significantly related to the Framingham and Reynolds CVD risk predictors, but were no longer significant after correction for confounders. The same applied to the significant relations between tooth loss, dental plaque and bleeding scores and the CVD risk predictors. Conclusions: Periodontitis is associated with increased CVD risk, but is not an independent risk factor. This link is still important to make to bridge the gap between dentistry and general medicine and to identify patients at risk for CVD in an earlier stage.http://www.sciencedirect.com/science/article/pii/S277248752100012XPeriodontitisDental healthCardiovascular diseaseCoronary artery calcium (CAC) scoreCVD risk PredictionCVD prevention |
| spellingShingle | H.C.M. Donders E.O. Veth A.W.J. van ‘t Hof J. de Lange B.G. Loos The association between periodontitis and cardiovascular risks in asymptomatic healthy patients International Journal of Cardiology. Cardiovascular Risk and Prevention Periodontitis Dental health Cardiovascular disease Coronary artery calcium (CAC) score CVD risk Prediction CVD prevention |
| title | The association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| title_full | The association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| title_fullStr | The association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| title_full_unstemmed | The association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| title_short | The association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| title_sort | association between periodontitis and cardiovascular risks in asymptomatic healthy patients |
| topic | Periodontitis Dental health Cardiovascular disease Coronary artery calcium (CAC) score CVD risk Prediction CVD prevention |
| url | http://www.sciencedirect.com/science/article/pii/S277248752100012X |
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