Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections
The nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous pathogens, including SARS-CoV-2, <i>S. pneumoniae</i>, <i>S. aureus</i>, etc., can adhere/colonize nasal lining to trigger an infection. Secretory IgA (sIgA) serves as the first line...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Immuno |
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| Online Access: | https://www.mdpi.com/2673-5601/2/4/36 |
| _version_ | 1797457149457072128 |
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| author | John Joseph |
| author_facet | John Joseph |
| author_sort | John Joseph |
| collection | DOAJ |
| description | The nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous pathogens, including SARS-CoV-2, <i>S. pneumoniae</i>, <i>S. aureus</i>, etc., can adhere/colonize nasal lining to trigger an infection. Secretory IgA (sIgA) serves as the first line of immune defense against foreign pathogens. sIgA facilitates clearance of pathogenic microbes by intercepting their access to epithelial receptors and mucus entrapment through immune exclusion. Elevated levels of neutralizing IgA at the mucosal surfaces are associated with a high level of protection following intranasal immunizations. This review summarizes recent advances in intranasal vaccination technology and challenges in maintaining nominal IgA levels at the mucosal surface. Overall, the review emphasizes the significance of IgA-mediated nasal immunity, which holds a tremendous potential to mount protection against respiratory pathogens. |
| first_indexed | 2024-03-09T16:18:01Z |
| format | Article |
| id | doaj.art-b17977eb3c9b48a0ac5d67446a5cfd1d |
| institution | Directory Open Access Journal |
| issn | 2673-5601 |
| language | English |
| last_indexed | 2024-03-09T16:18:01Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj.art-b17977eb3c9b48a0ac5d67446a5cfd1d2023-11-24T15:36:20ZengMDPI AGImmuno2673-56012022-10-012457158310.3390/immuno2040036Harnessing Nasal Immunity with IgA to Prevent Respiratory InfectionsJohn Joseph0Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAThe nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous pathogens, including SARS-CoV-2, <i>S. pneumoniae</i>, <i>S. aureus</i>, etc., can adhere/colonize nasal lining to trigger an infection. Secretory IgA (sIgA) serves as the first line of immune defense against foreign pathogens. sIgA facilitates clearance of pathogenic microbes by intercepting their access to epithelial receptors and mucus entrapment through immune exclusion. Elevated levels of neutralizing IgA at the mucosal surfaces are associated with a high level of protection following intranasal immunizations. This review summarizes recent advances in intranasal vaccination technology and challenges in maintaining nominal IgA levels at the mucosal surface. Overall, the review emphasizes the significance of IgA-mediated nasal immunity, which holds a tremendous potential to mount protection against respiratory pathogens.https://www.mdpi.com/2673-5601/2/4/36secretory IgAIgA class switchingSARS-CoV-2respiratory pathogensnasal vaccinesvaccine adjuvants |
| spellingShingle | John Joseph Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections Immuno secretory IgA IgA class switching SARS-CoV-2 respiratory pathogens nasal vaccines vaccine adjuvants |
| title | Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections |
| title_full | Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections |
| title_fullStr | Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections |
| title_full_unstemmed | Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections |
| title_short | Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections |
| title_sort | harnessing nasal immunity with iga to prevent respiratory infections |
| topic | secretory IgA IgA class switching SARS-CoV-2 respiratory pathogens nasal vaccines vaccine adjuvants |
| url | https://www.mdpi.com/2673-5601/2/4/36 |
| work_keys_str_mv | AT johnjoseph harnessingnasalimmunitywithigatopreventrespiratoryinfections |