Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester
Methods for the synthesis of amides are extremely important given huge prevalence of this functional group in biological systems, as well as in the pharmaceutical industry. The ACS Green Chemistry Institute Pharmaceutical Roundtable have identified the amide bond formation as one of the most importa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715621001582 |
| _version_ | 1811200968972304384 |
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| author | Omolola Gbadebo Karen Fox Grace Sutton Paul V. Murphy Dennis Smith Patrick O'Leary |
| author_facet | Omolola Gbadebo Karen Fox Grace Sutton Paul V. Murphy Dennis Smith Patrick O'Leary |
| author_sort | Omolola Gbadebo |
| collection | DOAJ |
| description | Methods for the synthesis of amides are extremely important given huge prevalence of this functional group in biological systems, as well as in the pharmaceutical industry. The ACS Green Chemistry Institute Pharmaceutical Roundtable have identified the amide bond formation as one of the most important reactions used in industry for which better reagents are required. We have developed a mild method using simple esters and amines with a Grignard reagent to synthesise, amides, carbamates and ureas (symmetrical and unsymmetrical). The method is significant in its simplicity, wide scope and the molecules that can be accessed. |
| first_indexed | 2024-04-12T02:13:39Z |
| format | Article |
| id | doaj.art-b179a333d31645ffa1bfc40dc46734c0 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-12T02:13:39Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-b179a333d31645ffa1bfc40dc46734c02022-12-22T03:52:19ZengElsevierResults in Chemistry2211-71562022-01-014100253Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an esterOmolola Gbadebo0Karen Fox1Grace Sutton2Paul V. Murphy3Dennis Smith4Patrick O'Leary5SMACT, School of Chemistry, National University of Ireland, Galway, IrelandSMACT, School of Chemistry, National University of Ireland, Galway, IrelandSMACT, School of Chemistry, National University of Ireland, Galway, IrelandSMACT, School of Chemistry, National University of Ireland, Galway, IrelandSMACT, School of Chemistry, National University of Ireland, Galway, IrelandCorresponding author.; SMACT, School of Chemistry, National University of Ireland, Galway, IrelandMethods for the synthesis of amides are extremely important given huge prevalence of this functional group in biological systems, as well as in the pharmaceutical industry. The ACS Green Chemistry Institute Pharmaceutical Roundtable have identified the amide bond formation as one of the most important reactions used in industry for which better reagents are required. We have developed a mild method using simple esters and amines with a Grignard reagent to synthesise, amides, carbamates and ureas (symmetrical and unsymmetrical). The method is significant in its simplicity, wide scope and the molecules that can be accessed.http://www.sciencedirect.com/science/article/pii/S2211715621001582AmideCarbamateUreaSynthesisGrignard |
| spellingShingle | Omolola Gbadebo Karen Fox Grace Sutton Paul V. Murphy Dennis Smith Patrick O'Leary Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester Results in Chemistry Amide Carbamate Urea Synthesis Grignard |
| title | Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester |
| title_full | Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester |
| title_fullStr | Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester |
| title_full_unstemmed | Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester |
| title_short | Novel versatile synthesis method for amides, carbamates and ureas employing a Grignard base, an amine and an ester |
| title_sort | novel versatile synthesis method for amides carbamates and ureas employing a grignard base an amine and an ester |
| topic | Amide Carbamate Urea Synthesis Grignard |
| url | http://www.sciencedirect.com/science/article/pii/S2211715621001582 |
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