The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates
A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to organize cellular contents, it is not surprising th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.896305/full |
| _version_ | 1818278085819105280 |
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| author | Chuankai Zhou Chuankai Zhou |
| author_facet | Chuankai Zhou Chuankai Zhou |
| author_sort | Chuankai Zhou |
| collection | DOAJ |
| description | A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to organize cellular contents, it is not surprising that these membrane-less condensates interact with the membrane-bound organelles and are dynamically regulated by the cellular signaling, metabolic states, and proteostasis network. In this review, I will discuss recent progress in the biogenesis of membrane-less condensates and their connections with well-studied membrane-bound organelles. Future work will reveal the molecular and functional connectome among different condensates and membrane-bound organelles. |
| first_indexed | 2024-12-12T23:11:50Z |
| format | Article |
| id | doaj.art-b17c17833d0843d2b4dc92278317f562 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T23:11:50Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b17c17833d0843d2b4dc92278317f5622022-12-22T00:08:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.896305896305The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less CondensatesChuankai Zhou0Chuankai Zhou1Buck Institute for Research on Aging, Novato, CA, United StatesLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United StatesA major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to organize cellular contents, it is not surprising that these membrane-less condensates interact with the membrane-bound organelles and are dynamically regulated by the cellular signaling, metabolic states, and proteostasis network. In this review, I will discuss recent progress in the biogenesis of membrane-less condensates and their connections with well-studied membrane-bound organelles. Future work will reveal the molecular and functional connectome among different condensates and membrane-bound organelles.https://www.frontiersin.org/articles/10.3389/fcell.2022.896305/fullmembrane-bound organellesmembrane-less condensatesstress granulesprotein aggregatesphase separation |
| spellingShingle | Chuankai Zhou Chuankai Zhou The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates Frontiers in Cell and Developmental Biology membrane-bound organelles membrane-less condensates stress granules protein aggregates phase separation |
| title | The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates |
| title_full | The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates |
| title_fullStr | The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates |
| title_full_unstemmed | The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates |
| title_short | The Molecular and Functional Interaction Between Membrane-Bound Organelles and Membrane-Less Condensates |
| title_sort | molecular and functional interaction between membrane bound organelles and membrane less condensates |
| topic | membrane-bound organelles membrane-less condensates stress granules protein aggregates phase separation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.896305/full |
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