Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

<p>Abstract</p> <p>Background</p> <p>Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer.</p> <p>Methods</p> <p>To further understand Herc...

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Bibliographic Details
Main Authors: Kong Sun-Young, Lee Ho-Young, Kim Seok-Ki, Kwon Bumi, Kim Kyung-Hee, Kang Keon, Kang Se, Lee Eun, Jang Sang-Geun, Yoo Byong
Format: Article
Language:English
Published: BMC 2008-10-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/286

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