Normal pressure hydrocephalus, a possible complication in IgG4-related disease
We report a 75-year-old man with glucocorticoid-responsive normal pressure hydrocephalus (NPH) complicated with tubulointerstitial renal disease, protein-losing gastroenteropathy (PLG) and elevated serum IgG4, which might be a possible subset of IgG4-related disease (IgG4-RD). Although either PLG or...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-09-01
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| Series: | Interdisciplinary Neurosurgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751916300093 |
| _version_ | 1811239112596783104 |
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| author | Hiroshi Kobayashi Masaaki Uehara Aya Oda Erika Matsubara Hiroyuki Baba Ryo Matsumiya Noritada Yoshikawa Osamu Hosono Hirotoshi Tanaka |
| author_facet | Hiroshi Kobayashi Masaaki Uehara Aya Oda Erika Matsubara Hiroyuki Baba Ryo Matsumiya Noritada Yoshikawa Osamu Hosono Hirotoshi Tanaka |
| author_sort | Hiroshi Kobayashi |
| collection | DOAJ |
| description | We report a 75-year-old man with glucocorticoid-responsive normal pressure hydrocephalus (NPH) complicated with tubulointerstitial renal disease, protein-losing gastroenteropathy (PLG) and elevated serum IgG4, which might be a possible subset of IgG4-related disease (IgG4-RD). Although either PLG or NPH, especially in combination, has rarely been reported in IgG4-RD, the glucocorticoid-responsive nature of every abnormality observed in the patient supports the diagnosis of IgG4-RD. Of course, pathological confirmation is essential to fulfill the recently raised diagnostic criteria, however, such invasive procedure might not always be indicated in high-risk patients. Our report illustrates that IgG4-RD might be considered as one of the underlying causes and/or the aggravating factors of NPH before shunt operation. |
| first_indexed | 2024-04-12T12:54:07Z |
| format | Article |
| id | doaj.art-b17ec95037c749fdbd1482d4529f8790 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-12T12:54:07Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-b17ec95037c749fdbd1482d4529f87902022-12-22T03:32:22ZengElsevierInterdisciplinary Neurosurgery2214-75192016-09-015C1210.1016/j.inat.2016.03.009Normal pressure hydrocephalus, a possible complication in IgG4-related diseaseHiroshi Kobayashi0Masaaki Uehara1Aya Oda2Erika Matsubara3Hiroyuki Baba4Ryo Matsumiya5Noritada Yoshikawa6Osamu Hosono7Hirotoshi Tanaka8Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanDepartment of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, JapanWe report a 75-year-old man with glucocorticoid-responsive normal pressure hydrocephalus (NPH) complicated with tubulointerstitial renal disease, protein-losing gastroenteropathy (PLG) and elevated serum IgG4, which might be a possible subset of IgG4-related disease (IgG4-RD). Although either PLG or NPH, especially in combination, has rarely been reported in IgG4-RD, the glucocorticoid-responsive nature of every abnormality observed in the patient supports the diagnosis of IgG4-RD. Of course, pathological confirmation is essential to fulfill the recently raised diagnostic criteria, however, such invasive procedure might not always be indicated in high-risk patients. Our report illustrates that IgG4-RD might be considered as one of the underlying causes and/or the aggravating factors of NPH before shunt operation.http://www.sciencedirect.com/science/article/pii/S2214751916300093Normal pressure hydrocephalusIgG4-related diseaseGlucocorticoid |
| spellingShingle | Hiroshi Kobayashi Masaaki Uehara Aya Oda Erika Matsubara Hiroyuki Baba Ryo Matsumiya Noritada Yoshikawa Osamu Hosono Hirotoshi Tanaka Normal pressure hydrocephalus, a possible complication in IgG4-related disease Interdisciplinary Neurosurgery Normal pressure hydrocephalus IgG4-related disease Glucocorticoid |
| title | Normal pressure hydrocephalus, a possible complication in IgG4-related disease |
| title_full | Normal pressure hydrocephalus, a possible complication in IgG4-related disease |
| title_fullStr | Normal pressure hydrocephalus, a possible complication in IgG4-related disease |
| title_full_unstemmed | Normal pressure hydrocephalus, a possible complication in IgG4-related disease |
| title_short | Normal pressure hydrocephalus, a possible complication in IgG4-related disease |
| title_sort | normal pressure hydrocephalus a possible complication in igg4 related disease |
| topic | Normal pressure hydrocephalus IgG4-related disease Glucocorticoid |
| url | http://www.sciencedirect.com/science/article/pii/S2214751916300093 |
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