Current progress and questions in germline genetics of prostate cancer
Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
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| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388218300869 |
| _version_ | 1818525117752279040 |
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| author | William B. Isaacs Jianfeng Xu |
| author_facet | William B. Isaacs Jianfeng Xu |
| author_sort | William B. Isaacs |
| collection | DOAJ |
| description | Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. A major question exists about which additional populations of men to test, as men at all risk levels can potentially benefit by knowing their unique genetic profile of germline susceptibility variants. This article will provide a brief overview of some current issues in understanding inherited susceptibility for PCa. Keywords: Genetic susceptibility, BRCA2, Single-nucleotide polymorphisms, Mutations, Germline genetics, Prostate cancer |
| first_indexed | 2024-12-11T06:05:27Z |
| format | Article |
| id | doaj.art-b17f3186c6934ed4b4de1d8075582d5f |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-12-11T06:05:27Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-b17f3186c6934ed4b4de1d8075582d5f2022-12-22T01:18:18ZengElsevierAsian Journal of Urology2214-38822019-01-016139Current progress and questions in germline genetics of prostate cancerWilliam B. Isaacs0Jianfeng Xu1Brady Urological Institute, Johns Hopkins University, School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Corresponding author.North Shore University Health System, Research Institute, Evanston, IL, USADramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. A major question exists about which additional populations of men to test, as men at all risk levels can potentially benefit by knowing their unique genetic profile of germline susceptibility variants. This article will provide a brief overview of some current issues in understanding inherited susceptibility for PCa. Keywords: Genetic susceptibility, BRCA2, Single-nucleotide polymorphisms, Mutations, Germline genetics, Prostate cancerhttp://www.sciencedirect.com/science/article/pii/S2214388218300869 |
| spellingShingle | William B. Isaacs Jianfeng Xu Current progress and questions in germline genetics of prostate cancer Asian Journal of Urology |
| title | Current progress and questions in germline genetics of prostate cancer |
| title_full | Current progress and questions in germline genetics of prostate cancer |
| title_fullStr | Current progress and questions in germline genetics of prostate cancer |
| title_full_unstemmed | Current progress and questions in germline genetics of prostate cancer |
| title_short | Current progress and questions in germline genetics of prostate cancer |
| title_sort | current progress and questions in germline genetics of prostate cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2214388218300869 |
| work_keys_str_mv | AT williambisaacs currentprogressandquestionsingermlinegeneticsofprostatecancer AT jianfengxu currentprogressandquestionsingermlinegeneticsofprostatecancer |