Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention
Platinum-based antitumor drugs are broad-spectrum agents with unique mechanisms of action. Combination chemotherapy regimens based on platinum drugs are commonly used in cancer treatment. However, these drugs can cause various adverse reactions in the human body through different routes of administr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1327502/full |
| _version_ | 1827352849977180160 |
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| author | Zhan Jin Liu Zhao-Xia Peng Fan-Ke Zhang Wen-Juan Wei Min-Li Zeng Han-Yi Zeng Han-Yi |
| author_facet | Zhan Jin Liu Zhao-Xia Peng Fan-Ke Zhang Wen-Juan Wei Min-Li Zeng Han-Yi Zeng Han-Yi |
| author_sort | Zhan Jin |
| collection | DOAJ |
| description | Platinum-based antitumor drugs are broad-spectrum agents with unique mechanisms of action. Combination chemotherapy regimens based on platinum drugs are commonly used in cancer treatment. However, these drugs can cause various adverse reactions in the human body through different routes of administration, including reproductive toxicity, genetic toxicity, and embryonic developmental toxicity. Preventing adverse effects is crucial to enhance patients' quality of life and reduce healthcare costs. This article discusses the types and developmental history of antitumor active platinum compounds, their mechanisms of action, routes of administration, and their potential reproductive, genetic, and embryonic developmental toxicity. This text explores preventive measures based on animal experimental results. Its aim is to provide references for personalized treatment and occupational protection when using platinum drugs. The continuous progress of science and technology, along with the deepening of medical research, suggests that the application of platinum drugs will broaden. Therefore, the development of new platinum drugs will be an important direction for future research. |
| first_indexed | 2024-03-08T03:12:02Z |
| format | Article |
| id | doaj.art-b183ef370aeb452aa57e42e646836b1a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T03:12:02Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b183ef370aeb452aa57e42e646836b1a2024-02-13T04:24:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13275021327502Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of preventionZhan Jin0Liu Zhao-Xia1Peng Fan-Ke2Zhang Wen-Juan3Wei Min-Li4Zeng Han-Yi5Zeng Han-Yi6Gannan Medical University, Ganzhou, ChinaDepartment of Reproductive Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaBazhong Central Hospital, Bazhong, ChinaGannan Medical University, Ganzhou, ChinaDepartment of Reproductive Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Reproductive Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Genetics at the School of Basic Medicine, Gannan Medical University, Ganzhou, ChinaPlatinum-based antitumor drugs are broad-spectrum agents with unique mechanisms of action. Combination chemotherapy regimens based on platinum drugs are commonly used in cancer treatment. However, these drugs can cause various adverse reactions in the human body through different routes of administration, including reproductive toxicity, genetic toxicity, and embryonic developmental toxicity. Preventing adverse effects is crucial to enhance patients' quality of life and reduce healthcare costs. This article discusses the types and developmental history of antitumor active platinum compounds, their mechanisms of action, routes of administration, and their potential reproductive, genetic, and embryonic developmental toxicity. This text explores preventive measures based on animal experimental results. Its aim is to provide references for personalized treatment and occupational protection when using platinum drugs. The continuous progress of science and technology, along with the deepening of medical research, suggests that the application of platinum drugs will broaden. Therefore, the development of new platinum drugs will be an important direction for future research.https://www.frontiersin.org/articles/10.3389/fphar.2024.1327502/fullplatinumantitumorreproductive toxicitygenotoxicityembryonic developmental toxicity |
| spellingShingle | Zhan Jin Liu Zhao-Xia Peng Fan-Ke Zhang Wen-Juan Wei Min-Li Zeng Han-Yi Zeng Han-Yi Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention Frontiers in Pharmacology platinum antitumor reproductive toxicity genotoxicity embryonic developmental toxicity |
| title | Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention |
| title_full | Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention |
| title_fullStr | Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention |
| title_full_unstemmed | Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention |
| title_short | Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention |
| title_sort | progress in the study of reproductive toxicity of platinum based antitumor drugs and their means of prevention |
| topic | platinum antitumor reproductive toxicity genotoxicity embryonic developmental toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1327502/full |
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