Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/13238 |
| _version_ | 1797997576776056832 |
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| author | Qingqing Liu Xing Yang Jingsong Tian Zhongbao Gao Meng Wang Yan Li Aike Guo |
| author_facet | Qingqing Liu Xing Yang Jingsong Tian Zhongbao Gao Meng Wang Yan Li Aike Guo |
| author_sort | Qingqing Liu |
| collection | DOAJ |
| description | Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly’s visual learning and memory. |
| first_indexed | 2024-04-11T10:34:51Z |
| format | Article |
| id | doaj.art-b1854564798444f29dc1c9cee9fbd30e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:34:51Z |
| publishDate | 2016-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-b1854564798444f29dc1c9cee9fbd30e2022-12-22T04:29:20ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.13238Gap junction networks in mushroom bodies participate in visual learning and memory in DrosophilaQingqing Liu0Xing Yang1https://orcid.org/0000-0001-6710-0012Jingsong Tian2Zhongbao Gao3Meng Wang4Yan Li5Aike Guo6https://orcid.org/0000-0002-6515-7944State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, ChinaGap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly’s visual learning and memory.https://elifesciences.org/articles/13238gap junctionsoptogeneticsvisual learning and memory |
| spellingShingle | Qingqing Liu Xing Yang Jingsong Tian Zhongbao Gao Meng Wang Yan Li Aike Guo Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila eLife gap junctions optogenetics visual learning and memory |
| title | Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila |
| title_full | Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila |
| title_fullStr | Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila |
| title_full_unstemmed | Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila |
| title_short | Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila |
| title_sort | gap junction networks in mushroom bodies participate in visual learning and memory in drosophila |
| topic | gap junctions optogenetics visual learning and memory |
| url | https://elifesciences.org/articles/13238 |
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