An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources
Antimicrobial peptides (AMPs) are constituents of the innate immune system in every kind of living organism. They can act by disrupting the microbial membrane or without affecting membrane stability. Interest in these small peptides stems from the fear of antibiotics and the emergence of microorgani...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1483 |
| _version_ | 1797469363972866048 |
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| author | Irene Dini Margherita-Gabriella De Biasi Andrea Mancusi |
| author_facet | Irene Dini Margherita-Gabriella De Biasi Andrea Mancusi |
| author_sort | Irene Dini |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are constituents of the innate immune system in every kind of living organism. They can act by disrupting the microbial membrane or without affecting membrane stability. Interest in these small peptides stems from the fear of antibiotics and the emergence of microorganisms resistant to antibiotics. Through membrane or metabolic disruption, they defend an organism against invading bacteria, viruses, protozoa, and fungi. High efficacy and specificity, low drug interaction and toxicity, thermostability, solubility in water, and biological diversity suggest their applications in food, medicine, agriculture, animal husbandry, and aquaculture. Nanocarriers can be used to protect, deliver, and improve their bioavailability effectiveness. High cost of production could limit their use. This review summarizes the natural sources, structures, modes of action, and applications of microbial peptides in the food and pharmaceutical industries. Any restrictions on AMPs’ large-scale production are also taken into consideration. |
| first_indexed | 2024-03-09T19:20:22Z |
| format | Article |
| id | doaj.art-b185e7051f9f44e39d3500a0cfe6a747 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T19:20:22Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-b185e7051f9f44e39d3500a0cfe6a7472023-11-24T03:27:06ZengMDPI AGAntibiotics2079-63822022-10-011111148310.3390/antibiotics11111483An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural SourcesIrene Dini0Margherita-Gabriella De Biasi1Andrea Mancusi2Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici, ItalyAntimicrobial peptides (AMPs) are constituents of the innate immune system in every kind of living organism. They can act by disrupting the microbial membrane or without affecting membrane stability. Interest in these small peptides stems from the fear of antibiotics and the emergence of microorganisms resistant to antibiotics. Through membrane or metabolic disruption, they defend an organism against invading bacteria, viruses, protozoa, and fungi. High efficacy and specificity, low drug interaction and toxicity, thermostability, solubility in water, and biological diversity suggest their applications in food, medicine, agriculture, animal husbandry, and aquaculture. Nanocarriers can be used to protect, deliver, and improve their bioavailability effectiveness. High cost of production could limit their use. This review summarizes the natural sources, structures, modes of action, and applications of microbial peptides in the food and pharmaceutical industries. Any restrictions on AMPs’ large-scale production are also taken into consideration.https://www.mdpi.com/2079-6382/11/11/1483AMPsfood preservationfood shelf-lifeactive packagingGram-positive bacteriaGram-negative bacteria |
| spellingShingle | Irene Dini Margherita-Gabriella De Biasi Andrea Mancusi An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources Antibiotics AMPs food preservation food shelf-life active packaging Gram-positive bacteria Gram-negative bacteria |
| title | An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources |
| title_full | An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources |
| title_fullStr | An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources |
| title_full_unstemmed | An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources |
| title_short | An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources |
| title_sort | overview of the potentialities of antimicrobial peptides derived from natural sources |
| topic | AMPs food preservation food shelf-life active packaging Gram-positive bacteria Gram-negative bacteria |
| url | https://www.mdpi.com/2079-6382/11/11/1483 |
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