Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis
Abstract Aim To assess the effects of nasal decontamination on preventing surgical site infections (SSIs) in people who are Staphylococcus aureus carriers undergoing different types of surgeries and diverse measures of decolonization. Methods Relevant randomized controlled trials (RCTs) were identif...
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| Format: | Article |
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BMC
2020-07-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
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| Online Access: | http://link.springer.com/article/10.1186/s12941-020-00376-w |
| _version_ | 1828839097718800384 |
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| author | Jia Tang Jiangjin Hui Jing Ma Chen Mingquan |
| author_facet | Jia Tang Jiangjin Hui Jing Ma Chen Mingquan |
| author_sort | Jia Tang |
| collection | DOAJ |
| description | Abstract Aim To assess the effects of nasal decontamination on preventing surgical site infections (SSIs) in people who are Staphylococcus aureus carriers undergoing different types of surgeries and diverse measures of decolonization. Methods Relevant randomized controlled trials (RCTs) were identified through systematic searches of the PubMed, Embase, Web of science, and the Cochrane Library databases. The risk ratios (RRs) and 95% confidence intervals (CIs) were calculated and the effects model was chosen according to the heterogeneity. Subgroup analyses were performed according to different types of surgeries and measures of decolonization that Staphylococcus aureus carriers were applied. Results Twenty RCTs published between 1996 and 2019 involving 10,526 patients were included. Pooled results showed that the overall SSIs and pulmonary surgery SSIs presented with a statistical difference in measures of nasal decontamination (RR = 0.59 and 0.47, respectively, both p < 0.01). However, the associations between nasal decolonization and increased risks of SSIs in orthopedics surgery or cardiovascular surgery remained insignificant in studies. As for the diverse measures of nasal decontamination, 50% used mupirocin, 15% used chlorhexidine, 30% used different types of antimicrobial drugs, and 5% use others. The SSIs rate were decreased after chlorhexidine (RR = 0.474, 95% CI 0.259–0.864), while no significant difference was shown in the use of mupirocin (RR = 0.871, 95% CI 0.544–1.394). Conclusion It seems that nasal decolonization of Staphylococcus aureus may be associated with a reduction of SSIs in these patients, especially in patients who have been administered by pulmonary surgeries or treated with chlorhexidine. |
| first_indexed | 2024-12-12T19:15:55Z |
| format | Article |
| id | doaj.art-b187cb5845774ed3bc350a4642c82f6a |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-12T19:15:55Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-b187cb5845774ed3bc350a4642c82f6a2022-12-22T00:14:43ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112020-07-011911910.1186/s12941-020-00376-wNasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysisJia Tang0Jiangjin Hui1Jing Ma2Chen Mingquan3Department of Infectious Diseases and Hepatology, Huashan Hospital, Fudan UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Zhejiang UniversityDepartment of Endocrinology and Metabolism, Gansu Provincial HospitalDepartment of Infectious Diseases and Hepatology, Huashan Hospital, Fudan UniversityAbstract Aim To assess the effects of nasal decontamination on preventing surgical site infections (SSIs) in people who are Staphylococcus aureus carriers undergoing different types of surgeries and diverse measures of decolonization. Methods Relevant randomized controlled trials (RCTs) were identified through systematic searches of the PubMed, Embase, Web of science, and the Cochrane Library databases. The risk ratios (RRs) and 95% confidence intervals (CIs) were calculated and the effects model was chosen according to the heterogeneity. Subgroup analyses were performed according to different types of surgeries and measures of decolonization that Staphylococcus aureus carriers were applied. Results Twenty RCTs published between 1996 and 2019 involving 10,526 patients were included. Pooled results showed that the overall SSIs and pulmonary surgery SSIs presented with a statistical difference in measures of nasal decontamination (RR = 0.59 and 0.47, respectively, both p < 0.01). However, the associations between nasal decolonization and increased risks of SSIs in orthopedics surgery or cardiovascular surgery remained insignificant in studies. As for the diverse measures of nasal decontamination, 50% used mupirocin, 15% used chlorhexidine, 30% used different types of antimicrobial drugs, and 5% use others. The SSIs rate were decreased after chlorhexidine (RR = 0.474, 95% CI 0.259–0.864), while no significant difference was shown in the use of mupirocin (RR = 0.871, 95% CI 0.544–1.394). Conclusion It seems that nasal decolonization of Staphylococcus aureus may be associated with a reduction of SSIs in these patients, especially in patients who have been administered by pulmonary surgeries or treated with chlorhexidine.http://link.springer.com/article/10.1186/s12941-020-00376-wNasal decolonizationStaphylococcus aureusSurgical site infectionsMeta-analysis |
| spellingShingle | Jia Tang Jiangjin Hui Jing Ma Chen Mingquan Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis Annals of Clinical Microbiology and Antimicrobials Nasal decolonization Staphylococcus aureus Surgical site infections Meta-analysis |
| title | Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis |
| title_full | Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis |
| title_fullStr | Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis |
| title_full_unstemmed | Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis |
| title_short | Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis |
| title_sort | nasal decolonization of staphylococcus aureus and the risk of surgical site infection after surgery a meta analysis |
| topic | Nasal decolonization Staphylococcus aureus Surgical site infections Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12941-020-00376-w |
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