Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy?
Jing Wang,1– 4,* Yuying Shi,1,3,4,* Yan Liu,2 Wei Li,5 Hong Jiang,2 Hongbing Cai1,3,4 1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, People’s Republic of China; 2Department of Obstetrics and Gynecology, Xiangyang Central Hospita...
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Dove Medical Press
2020-11-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/is-there-a-survival-benefit-for-patients-with-advanced-ovarian-clear-c-peer-reviewed-article-CMAR |
| _version_ | 1819204580320215040 |
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| author | Wang J Shi Y Liu Y Li W Jiang H Cai H |
| author_facet | Wang J Shi Y Liu Y Li W Jiang H Cai H |
| author_sort | Wang J |
| collection | DOAJ |
| description | Jing Wang,1– 4,* Yuying Shi,1,3,4,* Yan Liu,2 Wei Li,5 Hong Jiang,2 Hongbing Cai1,3,4 1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, People’s Republic of China; 2Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 3Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, People’s Republic of China; 4Hubei Cancer Clinical Study Center, Wuhan, Hubei, People’s Republic of China; 5Department of Obstetrics and Gynecology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing Cai Department of Gynecological OncologyZhongnan Hospital of Wuhan University, NO. 169 Donghu Road, Wuchang District, Wuhan, Hubei 430071, People’s Republic of ChinaTel +86 15090961340Email chbsyy@whu.edu.cnHong JiangDepartment of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, NO. 136 Jinzhou Road, Xiangcheng District, Xiangyang, Hubei 441000, People’s Republic of ChinaEmail 619319023@qq.comPurpose: To provide a reference for clinicians, whether patients with advanced ovarian clear cell carcinoma (OCCC) require chemotherapy (CT) for more than 6 cycles after tumor debulking.Patients and Methods: A retrospective review was performed on 85 women diagnosed and treated for advanced OCCC. Outcomes of patients who underwent > 6 vs ≤ 6 cycles of CT were analyzed based on clinicopathological factors.Results: Among the 85 patients with advanced OCCC, 47 patients underwent ≤ 6 cycles of CT, and 38 patients underwent CT for over 6 cycles. Out of these, 49 patients had disease recurrence, and 35 died. The 2-year progression-free survival (PFS) for patients in the two groups was 51.5% and 42.2% (P＞0.05), respectively. The 2-year overall survival (OS) was 59.7% and 64.5%, respectively (P＞0.05), and the difference was not statistically significant. Multivariate analysis showed that residual tumor diameter was an independent risk factor for prognosis (PFS and OS). We divided the patients into three groups according to residual tumor diameter as 0 (R0), ≤ 1cm (R1), and > 1cm (R2). The prognosis of R0 was better than R1 and R2. Further studies found that patients who received postoperative adjuvant chemotherapy for over 6 cycles showed no difference in improved prognosis, regardless of residual tumor diameter.Conclusion: Patients with advanced OCCC who received more than 6 courses of adjuvant chemotherapy after surgery did not show improved prognosis. The residual tumor diameter is an independent indicator of prognosis in patients with advanced OCCC. Complete staging improves the prognosis of patients compared to the ideal or non-ideal cytoreductive surgery.Keywords: ovarian clear cell carcinoma, chemotherapy, residual tumor, prognosis, overall survival |
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| language | English |
| last_indexed | 2024-12-23T04:38:04Z |
| publishDate | 2020-11-01 |
| publisher | Dove Medical Press |
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| series | Cancer Management and Research |
| spelling | doaj.art-b1888906908a4db6bac7900d4076b2c62022-12-21T17:59:51ZengDove Medical PressCancer Management and Research1179-13222020-11-01Volume 12116311163859294Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy?Wang JShi YLiu YLi WJiang HCai HJing Wang,1– 4,* Yuying Shi,1,3,4,* Yan Liu,2 Wei Li,5 Hong Jiang,2 Hongbing Cai1,3,4 1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, People’s Republic of China; 2Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 3Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, People’s Republic of China; 4Hubei Cancer Clinical Study Center, Wuhan, Hubei, People’s Republic of China; 5Department of Obstetrics and Gynecology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing Cai Department of Gynecological OncologyZhongnan Hospital of Wuhan University, NO. 169 Donghu Road, Wuchang District, Wuhan, Hubei 430071, People’s Republic of ChinaTel +86 15090961340Email chbsyy@whu.edu.cnHong JiangDepartment of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, NO. 136 Jinzhou Road, Xiangcheng District, Xiangyang, Hubei 441000, People’s Republic of ChinaEmail 619319023@qq.comPurpose: To provide a reference for clinicians, whether patients with advanced ovarian clear cell carcinoma (OCCC) require chemotherapy (CT) for more than 6 cycles after tumor debulking.Patients and Methods: A retrospective review was performed on 85 women diagnosed and treated for advanced OCCC. Outcomes of patients who underwent > 6 vs ≤ 6 cycles of CT were analyzed based on clinicopathological factors.Results: Among the 85 patients with advanced OCCC, 47 patients underwent ≤ 6 cycles of CT, and 38 patients underwent CT for over 6 cycles. Out of these, 49 patients had disease recurrence, and 35 died. The 2-year progression-free survival (PFS) for patients in the two groups was 51.5% and 42.2% (P＞0.05), respectively. The 2-year overall survival (OS) was 59.7% and 64.5%, respectively (P＞0.05), and the difference was not statistically significant. Multivariate analysis showed that residual tumor diameter was an independent risk factor for prognosis (PFS and OS). We divided the patients into three groups according to residual tumor diameter as 0 (R0), ≤ 1cm (R1), and > 1cm (R2). The prognosis of R0 was better than R1 and R2. Further studies found that patients who received postoperative adjuvant chemotherapy for over 6 cycles showed no difference in improved prognosis, regardless of residual tumor diameter.Conclusion: Patients with advanced OCCC who received more than 6 courses of adjuvant chemotherapy after surgery did not show improved prognosis. The residual tumor diameter is an independent indicator of prognosis in patients with advanced OCCC. Complete staging improves the prognosis of patients compared to the ideal or non-ideal cytoreductive surgery.Keywords: ovarian clear cell carcinoma, chemotherapy, residual tumor, prognosis, overall survivalhttps://www.dovepress.com/is-there-a-survival-benefit-for-patients-with-advanced-ovarian-clear-c-peer-reviewed-article-CMARovarian clear cell carcinomachemotherapyresidual tumorprognosisoverall survival |
| spellingShingle | Wang J Shi Y Liu Y Li W Jiang H Cai H Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? Cancer Management and Research ovarian clear cell carcinoma chemotherapy residual tumor prognosis overall survival |
| title | Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? |
| title_full | Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? |
| title_fullStr | Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? |
| title_full_unstemmed | Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? |
| title_short | Is There a Survival Benefit for Patients with Advanced Ovarian Clear Cell Carcinoma Who Complete More Than 6 Cycles of Postoperative Chemotherapy? |
| title_sort | is there a survival benefit for patients with advanced ovarian clear cell carcinoma who complete more than 6 cycles of postoperative chemotherapy |
| topic | ovarian clear cell carcinoma chemotherapy residual tumor prognosis overall survival |
| url | https://www.dovepress.com/is-there-a-survival-benefit-for-patients-with-advanced-ovarian-clear-c-peer-reviewed-article-CMAR |
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