HER2 Amplification in p53-Mutated Endometrial Carcinomas
p53-mutated endometrial carcinomas tend to recur and develop distant metastases. Therefore, the detection of new potential therapeutic targets such as HER2 is particularly interesting. In this retrospective study, which considered over 118 endometrial carcinomas, the p53 mutation was detected in 29....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/5/1435 |
| _version_ | 1797615674625884160 |
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| author | Ambre Balestra Denis Larsimont Jean-Christophe Noël |
| author_facet | Ambre Balestra Denis Larsimont Jean-Christophe Noël |
| author_sort | Ambre Balestra |
| collection | DOAJ |
| description | p53-mutated endometrial carcinomas tend to recur and develop distant metastases. Therefore, the detection of new potential therapeutic targets such as HER2 is particularly interesting. In this retrospective study, which considered over 118 endometrial carcinomas, the p53 mutation was detected in 29.6% of cases. In these cases, the HER2 protein profile was studied via immunohistochemistry, and an overexpression of HER2 protein (++ or +++) was noted in 31.4%. The CISH technique was used in these cases to determine if gene amplification was present. In 18% of cases, the technique was not conclusive. Amplification of the HER2 gene was observed in 36.3% of cases and 36.3% of cases showed a polysomal-like aneusomy for centromere 17. Amplification was found in serous carcinomas, clear cell carcinomas and carcinosarcomas, highlighting the future potentiality of HER2-targeted therapies in these variants of aggressive carcinomas. |
| first_indexed | 2024-03-11T07:30:03Z |
| format | Article |
| id | doaj.art-b189b30793bc4505814d001dfe24c6f3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T07:30:03Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b189b30793bc4505814d001dfe24c6f32023-11-17T07:24:05ZengMDPI AGCancers2072-66942023-02-01155143510.3390/cancers15051435HER2 Amplification in p53-Mutated Endometrial CarcinomasAmbre Balestra0Denis Larsimont1Jean-Christophe Noël2Department of Gynecology, ULB-Erasme, HUB, 808 Route de Lennik, 1070 Bruxelles, BelgiumDepartment of Pathology, Institut Bordet, ULB-Erasme, HUB, 808 Route de Lennik, 1070 Bruxelles, BelgiumDepartment of Pathology, Institut Bordet, ULB-Erasme, HUB, 808 Route de Lennik, 1070 Bruxelles, Belgiump53-mutated endometrial carcinomas tend to recur and develop distant metastases. Therefore, the detection of new potential therapeutic targets such as HER2 is particularly interesting. In this retrospective study, which considered over 118 endometrial carcinomas, the p53 mutation was detected in 29.6% of cases. In these cases, the HER2 protein profile was studied via immunohistochemistry, and an overexpression of HER2 protein (++ or +++) was noted in 31.4%. The CISH technique was used in these cases to determine if gene amplification was present. In 18% of cases, the technique was not conclusive. Amplification of the HER2 gene was observed in 36.3% of cases and 36.3% of cases showed a polysomal-like aneusomy for centromere 17. Amplification was found in serous carcinomas, clear cell carcinomas and carcinosarcomas, highlighting the future potentiality of HER2-targeted therapies in these variants of aggressive carcinomas.https://www.mdpi.com/2072-6694/15/5/1435endometrial carcinomap53mutationHER2amplificationtargeted therapies |
| spellingShingle | Ambre Balestra Denis Larsimont Jean-Christophe Noël HER2 Amplification in p53-Mutated Endometrial Carcinomas Cancers endometrial carcinoma p53 mutation HER2 amplification targeted therapies |
| title | HER2 Amplification in p53-Mutated Endometrial Carcinomas |
| title_full | HER2 Amplification in p53-Mutated Endometrial Carcinomas |
| title_fullStr | HER2 Amplification in p53-Mutated Endometrial Carcinomas |
| title_full_unstemmed | HER2 Amplification in p53-Mutated Endometrial Carcinomas |
| title_short | HER2 Amplification in p53-Mutated Endometrial Carcinomas |
| title_sort | her2 amplification in p53 mutated endometrial carcinomas |
| topic | endometrial carcinoma p53 mutation HER2 amplification targeted therapies |
| url | https://www.mdpi.com/2072-6694/15/5/1435 |
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